BIOCHEMICAL AND PHARMACOLOGICAL INVESTIGATIONS

该方案的目标是扩大和加强 佛罗里达A&M大学（FAMU）调查人员的能力， 生物医学研究，为本科生提供“手- 关于”在科学研究的基本原理和 激励他们追求生物医学研究事业，以及 培养研究生在国家的最先进的研究， 生物医学科学，侧重于药理学、医学 化学、生物化学、分子生物学和毒理学。 的 拟议的研究计划将涉及使用实验室的研究 动物 这些次级项目有以下具体目标：（1） 佛罗里达种族人群中的药物多态性观察结果： (2)嘧啶核苷的电氧化研究：（3）31- 人肺癌的核磁共振研究 (4)甲状腺素诱导肌肉蛋白质合成研究 激素;（5）硒诱导的高血糖症研究：（6）合成 秋水仙碱和紫杉醇类似物作为微管蛋白探针的目标;（7） 作为抗癌剂的尿嘧啶衍生物的制备;（8） 几种N- 氨基四氢吡啶类;（9）MNR用于检测和 肺癌监测;（10）衍生物的研究 皮质类固醇代谢产物;（11）降钙素控制钙 （12）研究失重过程中的代谢; 生物钟有益作用的神经化学基础 毒品 分析程序包括光谱测定（如 紫外、红外、质子NMR、31-P NMR原子吸收）， 色谱工作（例如，TLC，GC，HPLC）和许多药理学 使用闪烁计数器的测定将在 这些调查。 研究生和本科生 将参与实验的计划和执行。

The objective of this program is to expand and strengthen the capabilities of Florida A&M University (FAMU) investigators in biomedical research, to provide undergraduate students with "hands- on" experience in the fundamentals of scientific research and to motivate them to pursue biomedical research careers as well as to train graduate students in state of the art research in the biomedical sciences with concentration in pharmacology, medicinal chemistry, biochemistry, molecular biology and toxicology. The proposed research program will involve studies using laboratory animals. The subprojects have the following specific aims: (1) Drug polymorphism observations among ethnic populations in Florida: (2) Electro-oxidation studies of pyrimidine nucleosides: (3) 31- P nuclear magnetic resonance (NMR) study of human lung carcinoma; (4) investigation of muscle protein synthesis, induced by thyroid hormone; (5) selenium induced hyperglycemia studies: (6) Synthetic goals for colchicine and taxol analogs as probes of tubulin; (7) Preparation of uracil derivatives as anticancer agents; (8) synthesis and biological activity determinations of some N- aminotetrahydropyridines; (9) Use of MNR for detection and monitoring of lung cancer; (10) Investigation of the derivatives of corticosteroid metabolites; (11) Calcitonin control of calcium metabolism during weightlessness; and (12) studies of the neurochemical basis of the beneficial effects of chronobiotic drugs. Analytical procedures including spectral determinations (e.g . ultraviolet, infrared, proton NMR, 31-P NMR atomic absorption), chromatographic work (e.g., TLC, GC, HPLC) and many pharmacological assays using scintillation counters will be routinely conducted in these investigations. Both the graduate and undergraduate students will be involved in the planning and execution of the experiments.