ECHO PLANAR 15T GRADIENT PROBE

我们要求为ECHO平面梯度探测器升级提供部分资金 约翰·霍普金斯大学的1.5T全身研究扫描仪 医学院。主要用户群由五个NIH资助的用户组成 首席研究人员和两名非NIH资助的研究人员都专注于 心功能的有限元测量方法研究 使用MRI标记方法的菌株。对这种设备的迫切需求 增加，因为进一步的结果表明数据显著恶化 以及与当前设备的局限性有关的模糊性，包括： 1)需要获得超过128个或更多心脏周期的心电门控图像， 2)无法冻结呼吸运动，以及3)生理 实验制剂在长时间内(超过3小时)不稳定 建议的实验所需的实验时间。改进 在实验的时间分辨率以及缩短 总实验时间的比例已经成为成功的关键 完成这一主要用户群体的项目。 第二组由三名调查人员组成，其中两人是由NIH资助的，他们将 分享仪器的使用情况，以获得对 脑肿瘤和脑缺血区内的扩散和灌流。这 将有助于回答以下基本问题。 (1)MRS测量是否取决于生理参数，如 肿瘤中的扩散和血流？(2)脑部 缺血，这些测量能区分不同程度的 缺血性损伤？ 我们要求升级我们的研究扫描仪，因为我们没有 满足研究的关键科学需求的其他替代方案 本文所述的项目。

We are requesting partial funding of an echoplanar gradient probe upgrade for the 1.5T whole body research scanner of the Johns Hopkins University School of Medicine. The major user group consists of five NIH-funded principal investigators and two non NIH-funded researchers all focusing on the investigation of myocardial function via measurement of finite strains using MRI tagging methods. Critical need for this equipment has increased because further results indicate significant data deterioration and ambiguity related to the limitations of current equipment, including: 1) the need to obtain ECG-gated images over 128 or more cardiac cycles, 2) the inability to freeze respiratory motion, and 3) the physiologic instability of the experimental preparation over the long (over 3 hours) experimental time required for the proposed experiments. Improvement in the temporal resolution of the experiments as well as the shortening of total experimental time has become critical to the successful completion of the projects of this major user group. A second group of three investigators, two of whom are NIH-funded, will share in the use of the instrument to obtain real-time evaluations of diffusion and perfusion within brain tumors and ischemic brain. This will help answer the following fundamental questions. (1) Are MRS measurements dependent upon physiologic parameters such as diffusion and blood flow in tumors? (2) In the context of cerebral ischemia, can these measurements differentiate different levels of ischemic injury? We are requesting this upgrade to our research scanner as we have no other alternative to address the critical scientific need of the research projects herein described.