PURCHASE OF AN NMR SPECTROMETER AND UPGRADE

这个建议是为了购买一台核磁共振仪 (NMR)光谱仪和现有仪器升级。 这 仪器和升级将提供PHS支持的用户群 具有常规质子和多核核磁共振工作能力 最低限度地需要适当追求他们的工作， 进行急需的2D NMR的能力， 变温实验 这些需求不能 充分满足现有部门仪器的要求。 八 由100多名研究人员组成的用户组， 博士后助理和技术人员将由 要求核磁共振和升级。 这些研究活动 小组构成了一个密集的计划，包括广泛的 在生物化学，医学和生物医学领域的最前沿的目标范围 化学学科。 基础和应用研究包括 研究致癌的分子机制; 改良药剂的合成;功能研究 细胞色素P-450的研究 海洋甾醇的化学和生物合成; 有机磷的生物降解和解毒; 脂多糖生物合成中断及其与 革兰阴性菌;药用甾体合成;抗生素 合成;抗肿瘤剂的合成;以及其他。

This proposal is for the purchase of a nuclear magnetic resonance (NMR) spectrometer and upgrade of an existing instrument. This instrument and upgrade will provide the PHS supported user group with the capacity for routine proton and multi nuclei NMR work minimally needed for the proper pursuit of their work and with the capability for conducting crucially needed 2D NMR and variable temperature experiments. These needs can not be adequately met by existing departmental instrumentation. Eight user groups composed of over 100 research associates, postdoctoral associates, and technicians will be serviced by the requested NMR and upgrade. The research activities of these groups constitute an intensive program encompassing a broad range of objectives at the forefront of biochemical, medicinal and chemical disciplines. Basic and applied studies include investigations on the molecular mechanism of carcinogenesis; the synthesis of improved medicinal agents; studies on the function and biochemistry of key enzymes; studies on cytochrome P-450 and its models; the chemistry and biosynthesis of marine sterols; biodegradation and detoxification of organophosphates; lipopolysaccharide biosynthesis disruption and its relationship to gram-negative bacteria; medicinal steroids synthesis; antibiotic synthesis; the synthesis of antitumor agents; and others.