SMALL BIOMOLECULE HIGH INTENSITY DIFFRACTOMETER

购买单晶X光机需要资金 带有高功率旋转阳极发电机和低电流的衍射仪 温度附件。目前的设备是一台老式的衍射仪 使用微弱的常规X射线源。它由一个 有20年历史的过时的计算机，它越来越频繁地出现故障 由于缺少备件，很难修理。这是请求 仪器设备将首次使埃默里大学的8名调查人员 与美国国立卫生研究院资助的13个研究项目相关的大学 在原子水平上的详细结构信息 晶体样品(I)太小(&lt；0.1 mm平均边长)(Ii) 衍射太弱，或(Iii)相对于 去溶或热分解将由现有的 埃默里的X射线结晶学能力。收购 详细的X射线晶体结构信息现已取得成功 一系列计划和请求中的限制因素 工具将立即和持久地影响 获得大量资助的研究的有效性。 受影响的美国国立卫生研究院计划包括：(I)开发抗艾滋病药物 和肾脏显像剂的诊断，(Ii)合成 抗癌药物、DNA结构的分子探针和模型化合物 金属蛋白中铁中心的研究，以及(Iii)对 与脂类相关的分子聚集体。 X光设备将设在化学系，以及 由内部员工精心管理和维护，这些员工将接受 这就是目的。该设施将向许多其他公司提供 埃默里大学姊妹院校的生物医学研究人员 埃默里医学院、疾病控制中心、美国 癌症协会、埃默里·耶克斯灵长类中心和退伍军人中心 行政医疗中心)和其他NIH资助的研究人员 亚特兰大地区。

Funds are requested for the purchase of a single crystal X-ray diffractometer with a high power rotating anode generator and a low temperature accessory. The present facility is an old diffractometer with a weak conventional X-ray source. It is controlled by a twenty-year old, obsolete computer, which fails increasingly often and is difficult to repair for lack of spare parts. This requested instrumentation will enable for the first time 8 investigators at Emory University associated with 13 NIH supported research programs to garner detailed structural information at an atomic level for a myriad of crystalline samples which are (i) too small (< 0.1 mm average side) (ii) too weakly diffracting, or (iii) too unstable with respect to desolvation or thermal decomposition to be examined by the existing X-ray crystallographic capabilities at Emory. The acquisition of detailed X-ray crystallographic structural information is now a success limiting factor in a number of programs and the requested instrumentation will have immediate as well as lasting impact on the efficacy of considerable funded research. Affected NIH programs include (i) the development of anti-AIDS agents and diagnostic agents for renal imaging, (ii) the synthesis of anticancer drugs, molecular probes of DNA structure, and model compounds of iron centers in metalloproteins, and (iii) the investigation of molecular aggregates related to lipids. The X-ray facility will be housed in the Chemistry Department, and carefully run and maintained by in-house staff who will be trained for this purpose. The facility will be made available to a number of other biomedical investigators at Emory University's sister institutions (Emory Medical School, the Centers for Disease Control, the American Cancer Society, the Emory Yerkes Primate Center, and the Veteran's Administration Medical Center) and to other NIH-funded investigators in the Atlanta area.