Colon Cancer: Receptors, Signalling and Therapeutics

该项目旨在了解结直肠癌的生化和生物学基础，结直肠癌是澳大利亚癌症死亡的主要原因。首席研究员在分析结直肠癌细胞的分子缺陷方面拥有丰富的经验，并已开发出成功治疗实验性动物结肠肿瘤的新药。在这个研究项目中，我们将进一步探索这些系统，集中于结肠癌细胞生长、存活和运动的新型抑制剂的鉴定。新开发的仪器和技术将使我们能够识别和检测结直肠癌发展过程中的关键步骤，并设计出有效的药物来对抗这种疾病。我们在开展结肠癌的新型临床试验方面有经验，并开发了用于监测新型抗癌药物有效性和安全性的成像技术。我们在临床工作的集体科学经验和能力为开发更有效的结直肠癌患者治疗提供了独特的机会。

This program aims to understand the biochemical and biological basis of colorectal cancer, a major cause of cancer deaths in Australia. The Chief Investigators have extensive experience in the analysis of the molecular defects in colorectal cancer cells and have already developed new drugs to treat successfully experimental colon tumours in animals. During this research program, we will explore these systems further, concentrating on the identification of novel inhibitors of colon cancer cell growth, survival and movement. Newly developed instruments and techniques will allow us to identify and detect the critical steps during the development of colorectal cancer and to design potent drugs to fight the disease. We have experience in conducting novel clinical trials in colon cancer and have developed imaging techniques for monitoring the effectiveness and safety of new anti-cancer drugs. Our collective scientific experience and ability to work in the clinic provides a unique opportunity for developing more effective treatments for colorectal cancer patients.