Combating bacterial ‘superbugs‘ by innovative dosing strategies that combine available antibiotics to prevent resistance

由于耐药细菌“超级细菌”是对全球健康的三大最严重威胁之一，而且缺乏新的抗生素，因此迫切需要防止细菌耐药的创新战略。这一建议将对目前β -内酰胺类抗生素的最佳组合产生分子见解，以最大限度地杀死细菌而不产生耐药性。该项目将指导医生如何最佳地组合现有的β -内酰胺类抗生素，以防止细菌耐药性。

As resistant bacterial ‘superbugs’ are among the 3 most serious threats to global health and as new antibiotics are lacking, innovative strategies to prevent bacterial resistance are urgently needed. This proposal will yield molecular insights on optimal combinations of current beta-lactam antibiotics to maximise bacterial killing without resistance. This project will provide guidance to physicians on how to optimally combine available beta-lactam antibiotics to prevent bacterial resistance.