EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine

分子科学，如化学、生物物理学、分子生物学和蛋白质科学，对医学创新和发现新的药物和诊断方法至关重要。除了对健康和社会作出重要贡献外，这一领域的工业是经济的重要组成部分，为就业数字作出了巨大贡献，目前在全国创造了近50万个就业岗位。为了实现和促进这一领域未来的经济增长，CDT将提供一批在这一界面的两个方面都受过培训的研究人员，他们将成为各自领域未来的创新者和领导者。所有项目都将以分子科学和医学为基础，并将重点放在未满足的医疗需求上，例如对疾病生物学的理解，新的治疗靶点的确定，以及发现和开发新疗法的新方法。具体问题将由CDT内部的研究人员、工业合作伙伴、利益相关者和CDT学生确定。研究将围绕三个主题领域进行：疾病生物学、分子和分析设计以及结构生物学和计算。CDT汇集了领先的研究人员，他们在这些领域有良好的记录，并在该领域率先取得了最新进展，例如多种已批准的癌症治疗方法。他们的综合专业知识将为学生群体提供监督和指导，这些学生将从事跨越这些研究主题的项目，并为所讨论的医学问题做出贡献。学生队列方法将允许研究人员团队在共同目标的联合项目上一起工作。项目将由学者、工业合作伙伴和学生提出，与工业相关的项目优先考虑。跨学科的研究和培训计划将使CDT的毕业生具备前所未有的跨学科知识和技能背景。各学科的研究和培训方案将辅以企业家精神、负责任的创新和项目管理方面的培训和实践经验。综上所述，这将使CDT的毕业生非常受雇主欢迎，使他们具备设想和实施该领域未来创新所需的技能，并使他们成为未来的领导者。一个由主任、联席主任、主题负责人和培训协调员组成的结构合理、经验丰富的管理小组将在行业合作伙伴和学生的全面参与下监督CDT的执行。这将确保提供队列培训计划和联合活动，并对项目选择和学生招聘过程负责。管理团队在工业界和学术界以及科学领导和网络培训协调领域的研究和培训方面有着良好的记录。CDT将作为纽卡斯尔大学和达勒姆大学之间的一个单一的、完全整合的项目，将两所大学高度互补的技能和背景结合在一起。这两所大学与高效的交通联系和已建立的区域网络的独特联系，使该计划能够在两所大学之间无缝交付。CDT的概念和结构是与制药、生物技术和合同研究行业的工业伙伴共同制定的，他们对CDT在这一领域的可取性和培训需求以及主题领域和研究重点的性质给予了重要指导。EPSRC对CDT的资助将得到两所大学的资源和学生资助以及行业合作伙伴的大量贡献的补充，这些合作伙伴将提供培训，实物贡献和实习机会以及额外的学生。

Molecular sciences, such as chemistry, biophysics, molecular biology and protein science, are vital to innovations in medicine and the discovery of new medicines and diagnostics. As well as making a crucial contribution to health and society, industries in this field provide an essential component to the economy and contribute hugely to employment figures, currently generating nearly 500,000 jobs nationally.To enable and facilitate future economic growth in this area, the CDT will provide a cohort of researchers who have training in both aspects of this interface who will be equipped to become the future innovators and leaders in their field.All projects will be based in both molecular and medical sciences and will focus on unmet medical needs, such as understanding of disease biology, identification of new therapeutic targets, and new approaches to discovery and development of novel therapies. Specific problems will be identified by researchers within the CDT, industrial partners, stakeholders and the CDT students. The research will be structured around three theme areas: Biology of Disease, Molecule and Assay Design and Structural Biology and Computation. The CDT brings together leading researchers with a proven track record across these areas and who have pioneered recent advances in the field, such as multiple approved cancer treatments. Their combined expertise will provide supervision and mentorship to the student cohort who will work on projects that span these research themes and bring their contributions to bear on the medical problems in question. The student cohort approach will allow teams of researchers to work together on joint projects with common goals. Projects will be proposed between academics, industrial partners and students with priority given to those with industrial relevance.The programme of research and training across the disciplines will equip graduates of the CDT with an unprecedented background of knowledge and skills across the disciplines. The programme of research and training across the disciplines will be supplemented by training and hands-on experiences of entrepreneurship, responsible innovation and project management. Taken together this will make graduates of the CDT highly desirable to employers, equip them with the skills they need to envisage and implement future innovations in the area and allow them to become the leaders of tomorrow.A structured and highly experienced management group, consisting of a director, co-directors, theme leads and training coordinators will oversee the execution of the CDT with the full involvement of industry partners and students. This will ensure delivery of the cohort training programme and joint events as well as being accountable for the process of selection of projects and student recruitment. The management team has an established track record of delivery of research and training in the field across industry and academia as well as scientific leadership and network training coordination.The CDT will be delivered as a single, fully integrated programme between Newcastle and Durham Universities, bringing together highly complementary skills and backgrounds from the two institutions. The seamless delivery of the programme across the two institutions is enabled by their unique connectivity with efficient transport links and established regional networks.The concept and structure of the CDT has been developed in conjunction with the industrial partners across the pharmaceutical, biotech and contract research industries, who have given vital steer on the desirability and training need for a CDT in this area as well as to the nature of the theme areas and focus of research. EPSRC funding for the CDT will be supplemented by substantial contributions from both Universities with resources and studentship funding and from industry partners who will provide training, in kind contribution and placements as well as additional studentships.