RADIOLOGICAL DIAGNOSTIC ONCOLOGY GROUP

本申请是对RFA 86-CA-10，国家 协作成像跟踪项目。 我们组织了一个小组 成立放射诊断肿瘤学小组 （RDOG）。 合作小组将提供一种手段， 由此可以对诊断成像测试进行功效研究， 及时制定，从而可以分析数据 准确的方式。 在一个运营中心的支持下 以及统计和数据管理小组，我们将建立一个 持续的机制，以：优化图像质量， 参与研究中心;获得一致和完整的数据 参与研究中心;创建成像库，以允许衍生 在随后的几年里进行研究;并分析成像数据， 有效性和潜在的算法开发， 适当的分析技术。 所采用的技术 分析将是最先进的，涉及接收机操作 特性曲线分析;应特别注意确保 修正了一些可能妨碍准确的 数据分析 该应用程序解决了肺和前列腺的分期问题 癌 X线平片、CT和MRI的绝对值 非小细胞支气管炎患者的分期 将确定癌; MRI的增量值超过 还将评估CT。 对于前列腺癌分期， MRI和经直肠超声检查的准确性将在 无论是绝对的还是增量的。

This application is in response to RFA 86-CA-10, National Collaborative Imaging Trails Project. We have organized a group of institutions to form the Radiologic Diagnostic Oncology Group (RDOG). The collaborative group will be designed to provide a means whereby efficacy studies on and diagnostic imaging tests can be instituted in a timely fashion and whereby data can be analyzed in a accurate manner. Under the auspices of an operations center and statistical and data management group, we will establish an ongoing mechanism to: optimize image quality across all participating sites; obtain consistent and complete data across participating sites; create an imaging library to allow derivative studies in subsequent years; and analyze imaging data for clinical effectiveness and potential algorithm development using appropriate analytic techniques. The techniques employed for analysis will be state-of-the-art involving receiver operating characteristic curve analysis; special care will be taken to ensure correction for a number of biases that might preclude accurate data analyses. The application addresses the staging of both lung and prostate cancer. The absolute value of plain radiographs, CT, and MRI in the staging of patients with non-small-cell bronchogenic carcinoma will be determined; the incremental value of MRI over CT will also be assessed. For staging prostate cancer the accuracy of MRI and transrectal sonography will be determined in both absolute and incremental ways.