BREAST CANCER--SPECIFIC CELLULAR IMMUNITY AND BEHAVIOR

拟议研究的长远目标是减少 通过免疫对照妇女预防乳腺癌风险(BCA) 侵袭前BCA的细胞免疫(CMI)决定因素。 近期目标是：a)将以下风险联系起来 转移与核分化程度(核 主要BCA和皮肤窗口(Sw)反应性的等级 针对自体BCA组织，b)与第二次 具有针对第一个BCA和/或 RIII-鼠乳腺肿瘤病毒的gp55组分。这些 目标是根据校长先前的观察得出的 研究人员和同事就预后意义进行了讨论 前瞻分类NG和SW反应性：1.NG反之 与BCA早期转移的风险相关；2.短波 与NG特征的自体BCA的反应性相反 与早期转移的风险相关；3.短波反应性 对抗自体BCA的风险与 在随后的四年内第二次侵袭性的BCA；4. 具有预后意义的BCA免疫原的特征是 Cmi决定簇，类似于gp55；5.类似gp55的 CMI决定簇在 乳腺癌变的侵袭前阶段；因此，短波反应性 Gp55与侵袭性胆囊癌的风险呈负相关。 在接下来的四年里。 拟议的前瞻性研究将确定这些 在下列情况下可以重现研究结果：1. 结论：1.不同地域BCA患者的参与情况； 编码下所有原发BCA的形态分类 条件；3.对自体BCA的软件反应性测试 Gp55在规定的术后间隔，由不同的人执行 团队；4.编码条件下的软件测试结果评估；5. 由一个中心对所有数据进行整理和统计评估 在NCI注册。 Ng与Sw的相关性意义的确认 与BCA后续行为的反应性将是重要的 关于a)当前治疗的个体化和b) 免疫预防的发展。

The long-term objective of the proposed study is to reduce the risk of breast cancer (BCa) by immunizing control women against a cell-mediated immunity (CMI) determinant of preinvasive BCa. The immediate objectives are: a) correlating the risk of metastases with the degree of nuclear differentiation (nuclear grade, NG) of the primary BCa and skin window (SW) reactivity against autologous BCa tissue, b) correlating the risk of second primary BCa with SW reactivity against the first BCa and/or the gp55 component of the RIII-murine mammary tumor virus. These objectives are derived from prior observations by the Principal Investigator and associates on the prognostic significance of prospectively classified NG and SW reactivity: 1. NG is inversely correlated with the risk of early metastases from BCa; 2. SW reactivity against NG-characterized autologous BCa in inversely correlated with the risk of early metastases; 3. SW reactivity against autologous BCa is inversely correlated with the risk of a second invasive BCa within the subsequent four years; 4. the prognostically significant immunogen of BCa is characterized by a CMI determinant which is similar to one of gp 55; 5. this gp55-like CMI determinant is characteristically expressed during the preinvasive phase of mammary carcinogenesis; thus, SW reactivity to gp55 is inversely correlated with the risk of an invasive BCa within the subsequent four years. The proposed prospective study will determine whether these findings can be reproduced under the following conditions: 1. participation of BCa patients from different geographic areas; 2. morphologic classification of all primary BCa under coded conditions; 3. tests of SW reactivity against autologous BCa and gp55 at defined postoperative intervals, performed by different teams; 4. evaluation of SW test results under coded conditions; 5. collation and statistical evaluation of all data by a central registry at the NCI. Confirmation of the significance of the correlation of NG and SW reactivity with subsequent behavior of BCa would be important with regard to a) individualization of current therapy and b) development of immunoprophylaxis.