NATIONAL COLLABORATIVE DIAGNOSTIC IMAGING TRIAL PROJECTS

本申请是对FA 88-CA-02：National Collaborative的响应 诊断成像试验项目。医学成像的快速发展使 在过去10年中发生了相关的成本增加 成像程序。鉴于许多可用的模式，在临床上 高效且经济高效的诊断成像策略需要 被开发出来。这项建议的长期目标是评估 相关影像模式在诊断和治疗中的相对作用 结直肠癌和胰腺癌的分期。具体地说，相对 计算机断层扫描(CT)和磁共振成像(MRI)的准确性 在检测肝转移时将被确定。精确度 胃肠道造影、CT、MRI、B超和血管造影术 将根据他们上演地方区域范围的能力进行评估 结直肠癌和胰腺癌。使用接收器工作特性 曲线，我们将分别比较每种模式的性能和 然后在具体相关异常的诊断中联合 尝试为结直肠癌分期确定适当的诊断标准 和胰腺癌，以及每种方式的最佳使用。CT的作用， 而核磁共振在监测结直肠癌患者方面也将 在接下来的24个月内通过连续检查进行测试 初步治疗。提出了详细的病理相关性作为衡量标准。 对于局部区域范围和肝转移的真实性。数据 通过这项前瞻性研究获得的信息将构成开发 优化决策树在结直肠癌和胰腺癌成像中的应用。

This application is in response to FA 88-CA-02: National Collaborative Diagnostic Imaging Trail Projects. Rapid advances in medical imaging have occurred in the past 10 years with associated increases in the cost of imaging procedures. In view of the many available modalities, clinically efficient as well as cost effective diagnostic imaging strategies need to be developed. The long term objective of this proposal is to evaluate the relative roles of the relevant imaging modalities in the diagnosis and staging of colorectal and pancreatic cancer. Specifically, the relative accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in the detection of liver metastases will be determined. The accuracy of gastrointestinal barium studies, CT, MRI, ultrasonography and angiography will be evaluated in their ability to stage the loco-regional extent of colorectal and pancreatic cancer. Using receiver operating characteristic curves, we will compare the performance of each modality separately and then jointly in the diagnosis of the specific relevant abnormalities and attempt to determine appropriate diagnostic criteria for staging colorectal and pancreatic cancer and optimal use of each modality. The role of CT, and MRI in the monitoring of patients with colorectal cancer will also be tested through sequential examinations within the first 24 months after initial therapy. Detailed pathologic correlations are proposed as measures of truth for both loco-regional extent and hepatic metastases. The data acquired through this prospective study will form the basis for developing optimized decision trees in imaging of colorectal and pancreatic cancer.