A comprehensive immunoproteomic analysis of the repertoire and dynamics of human antibody responses to malaria

疟疾感染了10%的人类，每年导致200多万儿童死亡。我们开发了一种强大的新方法，在疾病免疫发展的关键时期，全面描述巴新儿童对疟疾寄生虫的抗体反应。拟议的工作将有助于我们更好地了解自然获得性免疫的目标和机制，并优先发展未来的治疗性疫苗、药物或诊断。

Malaria infects 10% of humanity and kills more than two million children annually. We have developed a powerful new approach to comprehensively profile antibody responses against the malaria parasite in PNG children during the critical period of development of disease immunity. The proposed work will help us to better understand the targets and mechanisms of naturally acquired immunity and prioritise the development of future thereapeutic vaccines, drugs or diagnostics.