EPSRC Capital Award for Core Equipment: Transformative Upgrade of NMR Facilities

该提案的主要目标是大幅提高利物浦大学物理科学学院核磁共振设备的能力和吞吐量，以支持我们在EPSRC职权范围内的世界领先研究活动，包括新材料设计，能源和催化领域，以及一些医疗保健化学项目。在这次变革性的升级中，UoL的材料研究将从液氮冷却的宽带Prodigy CryoProbe提供的更高灵敏度中受益，这将允许获得表征前体和功能分子所需的高质量不敏感核光谱以及难溶性材料的光谱。高通量材料发现需要快速、高通量的产品分析，这将通过SampleCase Plus自动化系统提供的改进的周转时间和效率来实现。在能源和催化领域，大部分研究只需要对中等敏感或不敏感的异核和变温能力进行核磁共振研究，这将通过液氮冷却宽带Prodigy CryoProbe实现。生物技术和医疗保健领域的UoL研究强烈依赖于少量化合物的多维高分辨率NMR实验，即检测不稳定的反应中间体和代谢物，这些实验在我们的环境温度探针上非常耗时或不切实际，而宽带Prodigy CryoProbe将在这一变革性升级中实现。

The main objective of this proposal is to dramatically enhance the capabilities and throughput of the NMR facilities within the School of Physical Sciences/University of Liverpool that underpins our world leading research activities within the remit of EPSRC, including those in the field of Design of New Materials, Energy and Catalysis, as well as in a number of Healthcare chemistry projects. Upon this transformative upgrade, Materials research in the UoL will benefit in several ways from the increased sensitivity provided by the liquid nitrogen cooled, broadband Prodigy CryoProbe that will allow high quality spectra of the insensitive nuclei required for the characterization of precursors and functional molecules and spectra of poorly soluble materials to be obtained. High throughput materials discovery requires rapid, high throughput analysis of products which will be enabled by the improved turnaround times and efficiency afforded by the SampleCase Plus automation system. In the field of Energy and Catalysis, much of this research requires NMR studies of only moderately sensitive or insensitive heteronuclei and variable temperature capabilities which will be enabled by the liquid nitrogen cooled broadband Prodigy CryoProbe. UoL research in Biotechnology and Healthcare rely strongly on multidimensional highly resolved NMR experiments of compounds available only in small amount, i.e. in detection of unstable reaction intermediates and metabolites, and these experiments, that are extremely time-consuming or impractical on our ambient temperature probes, will be enabled by the broadband Prodigy CryoProbe upon this transformative upgrade.