EFFECTS OF METALS AND PROTEINS ON NUCLEIC ACIDS, INFORMATION TRANSFER AND AGING

这个项目的重点是与遗传有关的分子之间的相互作用 信息传递 一个主要目标是确定 金属离子对信息传递是必不可少的，在什么条件下， 它们对信息产生影响的方式， 生物老化 感兴趣的主题有：（1）金属离子的影响 对核酸、核蛋白和染色质结构的影响;（2） 铝参与阿尔茨海默病的机制;（3） 通过金属离子交联核酸链;（4） RNA聚合酶活性位点;（5）金属离子与细胞衰老。

This project focuses on the interaction of molecules concerned with genetic information transfer. A primary objective is to determine under what conditions metal ions are essential for information tranfer, and under what conditions they impact on the information in such a way as to influence biological aging. Topics of interest are: (1) the effects of metal ions on the structure of nucleic acids, nucleoproteins and chromatin; (2) the mechanism of involvement of aluminum in Alzheimer's disease; (3) crosslinking of nucleic acid strands by metal ions; (4) the structure of the acitive site of RNA polymerase; (5) metal ions and cellular aging.