BARBADOS EYE STUDY

开角型青光眼是黑人视力损害的主要原因 人口。 临床经验表明， 青光眼风险在巴巴多斯，西弗吉尼亚州，那里的大多数公民都是非洲人 血统. 这种疾病是失明的主要原因， 早期和晚期视力丧失。 一项流行病学研究表明， 提出的主要目标是：a）衡量 青光眼及其相关损害，B）评估其风险 c）获取数据以制定干预措施， 或控制视力丧失。 这项研究将是第一个 全面的青光眼研究覆盖整个国家。 因为 这种疾病是黑人人口的一个主要问题， 拟议的研究具有广泛的公共卫生意义。 这项研究的次要目标是测量患病率， 评估年龄相关性白内障、黄斑 变性和糖尿病视网膜病变。 基于人群 关于这些疾病的流行病学数据有限或不存在 对于黑人人口;拟议的研究将提供这样的 以有限的额外费用提供信息。 上述目标将通过随机抽样检查 4000名40-84岁的人在卫生部的一家综合诊所接受治疗。 参与者将测量眼内压， 视野、视力、屈光、身高、体重和血液 压力，以及眼底照片和采访 病史、家族史和其他危险因素史。 血液检测 将在病例和非病例样本上进行。 评估本项目的可行性，并测试拟议的 招募和数据收集的方法， 进行。 参与试点研究的人口， 随机抽取了200人进行了调查，结果为95%。 黑衣 >54岁的人，视神经青光眼的患病率 损失为13%。 这些结果证实了青光眼的严重性 问题和研究的必要性。 因为它的结果 将适用于其他黑人人口，该研究有 可能对失明做出重要贡献 世界其他地区的预防。 进一步提升 所获得的数据的价值，研究计划包括一个重新- 对队列进行检查，以获得5年的发病率和自然发病率。 历史数据。

Open-angle glaucoma is a major cause of visual impairment in Black populations. Clinical experience suggests an unusually high glaucoma risk in Barbados, W.I., where most citizens are of African descent. The disease is the major cause of blindness, presenting early and with advanced visual loss. An epidemiologic study is proposed with the major goals of a) measuring the prevalence of glaucoma and its associated impairment, b) evaluating its risk factors, and c) obtaining data to develop interventions to prevent or control visual loss. The proposed research would be the first comprehensive glaucoma study to cover an entire country. Because the disease is a major problem in Black populations, the aims of the proposed study are of widespread public health significance. The secondary goals of the study are to measure prevalence and evaluate risk factors for age-related cataract, macular degeneration, and diabetic retinopathy. Population based epidemiologic data on these diseases are limited or non-existent for Black populations; the proposed study would provide such information at limited additional cost. The above goals would be attained by examining a random sample of 4000 persons 40-84 years in a Ministry of Health polyclinic. Participants would have measurements of intraocular pressure, visual fields, visual acuity, refraction, height, weight, and blood pressure, as well as fundus photographs and an interview on medical, family, and other risk factor history. Blood testing would be performed on cases and a sample of noncases. To assess the feasibility of this project and test the proposed methods of recruitment and data collection, a pilot study was undertaken. Population participation in the pilot study, which examined about 200 randomly selected persons, was 95%. In Black persons >54 years, the prevalence of glaucoma with optic nerve damage was 13%. These results confirm the severity of the glaucoma problem and the need for the proposed study. Because its results would be applicable to other Black populations, the study has the potential to make an important contribution toward blindness prevention in other parts of the world. To further enhance the value of the data obtained, the study plans include a re- examination of the cohort to obtain five-year incidence and natural history data.