INDIVIDUAL VARIABILITY IN DRUG METABOLISM BY CARBON DIOXIDE BREATH TESTS

咖啡因-二氧化碳呼气试验可能是一种有用的无创性措施 酒精中毒患者的氧化药物代谢和肝功能 咖啡因中13-C标记的甲基被去除并进一步氧化， 13-CO-2，通过同位素比质量在呼气样本中测量 光谱法10名受试者单次服用100 mg咖啡因， 酒精中毒患者，在患者最后一次饮酒后2至73天的时间间隔， 酒精饮料。呼气测试结果表示为累积 13-CO-2在2小时内排出。6名吸烟者和4名吸烟者的测试结果 比较了不吸烟者的结果，并对每例患者的结果变化进行了分析。 考察第一次测试的结果（最后一次饮酒后2至7天） 平均而言，吸烟者比不吸烟者高3.8倍 （p<0.01），表明吸烟者代谢更快。随着时间的推移，呼吸 2名吸烟者和3名非吸烟者的测试结果增加了20%以上， 试验结果下降20%以上者，提高到第一次试验结果的200%以上 2例为150%~ 200%。观察到的最大降幅 是第一次测量的57%。看来这个测试可以用来 来检测临床酗酒者

The caffeine-carbon dioxide breath test may be a useful nonivasive measure of oxidative drug metabolism and liver function in alcoholic patients. 13-C-labeled methyl groups in caffeine are removed and further oxidized to 13-CO-2, which was measured in expired breath samples by isotope ratio mass spectrometry. Single 100mg doses of caffeine were administered to 10 alcoholic patients, at intervals from 2 to 73 days after the patients' last alcoholic drink. The breath test results were expressed as the cumulative amount of 13-CO-2 expired in 2 hrs. The results of tests in 6 smokers and 4 nonsmokers were compared and the changes in results in each patient were examined. The results of the first test (2 to 7 days after the last drink) were, on the average, 3.8 times higher in smokers than in nonsmokers (p<0.01),indicating more rapid metabolism in smokers. Over time, the breath test results increased more than 20% in 2 smokers and 3 nonsmokers, but decreased more the 20% in test result was in-creased to >200% of the first measurement and in 2 patients to 150% - 200%. The maximum decrease observed was to 57% of the first measurement. It appears that this test can be used to detect clinical alcoholics.