IN VIVO NMR STUDIES OF AGING IN CELLS AND ANIMALS
IN VIVO NMR STUDIES OF AGING IN CELLS AND ANIMALS
细胞和动物衰老的体内核磁共振研究
批准号：
3808868
负责人：
GL EICHHORN
金额：
$0.0万
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
关键词：
Alzheimer's disease acid base balance aging arecoline brain disorder chemotherapy brain metabolism cell age cerebrospinal fluid cognition disorders creatine phosphate dopamine drug metabolism exercise haloperidol human subject muscle contraction muscle metabolism neurochemistry neuropharmacology neurotransmitter metabolism nuclear magnetic resonance spectroscopy personal computers pharmacokinetics pharmacology phosphates psychomotor function psychopharmacology pteridines
中文摘要
翻译
NMR光谱用于研究与以下相关的代谢变化：
在人类志愿者的前臂屈肌中进行锻炼。等距
在可变工作负荷以及恒定工作负荷下进行锻炼
使用连接到个人计算机和
显示单元
磷酸肌酸（PCr）和无机磷酸盐（Pi）以及
细胞内pH值通过（31）P NMR光谱监测，
锻炼的在运动过程中，这些参数的与血压相关的差异是
使用这些方案在BLSA的受试者中进行研究。
英文摘要
NMR Spectroscopy is used to study the metabolic changes associated with
exercise in the flexor muscle of the forearm of human volunteers. Isometric
exercise at variable workloads as well as constant workload are carried out
using a hand dynamometer which is interfaced to a personal computer and a
display unit.
Changes in phosphocreatine (PCr) and inorganic phosphate (Pi) as well as
intracellular pH are monitored via (31)P NMR spectroscopy during the
exercise. Age-related differences in these parameters during exercise are
studied in subjects of the BLSA using these protocols.
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