GCRF_NF437 High Performance Low Cost Ventilator (HPLV) project Cost Ventilator (HPLV) project

高性能低成本呼吸机(HPLV)项目解决的未得到满足的需求是经合组织发援会名单国家用于病人护理的呼吸机短缺。新冠肺炎的全球流行突显了呼吸机缺乏的问题，而可用于操作呼吸机的训练有素的人员短缺又加剧了这一问题。除了新冠肺炎之外，在经合组织的发改委名单国家中，仍然存在照顾肺炎患者和其他患有急性呼吸道疾病的患者的关键要求。该项目以日内瓦的欧洲核子研究中心粒子物理实验室在世卫组织的建议和指导下开发的HEV(高能物理呼吸机)为起点，目的是适合经合组织发改委名单的使用。混合动力汽车是利用欧洲核子研究组织研究中常规使用的技术开发的，包括用于气体输送和监管，以及用于复杂的监测和控制。然而，混合动力汽车的设计是价格合理、坚固耐用、易于维护，并能够在氧气供应压力可变、电力不可靠和训练有素的工作人员很少的环境中运行。其结果是一个具有弹性的简单设计，具有全面的内置远程培训、监控和操作选项，在性能和功能上都不会妥协，但允许通过多语言用户界面进行轻松操作。在这个HPLV项目中，巴西的合作伙伴将确定患者在进行呼吸机时遇到的局部困难，并将这些信息输入到致力于将HEV呼吸机重新设计为HPLV设计的设计团队。英国的监管专家也将就这一重组活动提供有价值的指导。除了根据来自巴西的真实建议重新设计HPLV原型之外，HPLV项目团队还将提供必要的文件来配合HPLV设计，以便它准备好接受监管部门的批准。这是一个关键的里程碑，使商业组织能够弥合医疗环境中使用的原型和制造之间的差距。当重新设计的HPLV原型在巴西成功测试，并且技术文件可供公司在许可设计制造并销售给OECD DAC列表用户时，该项目将达到终点。

The unmet need addressed by the High Performance Low-cost Ventilator (HPLV) project is the shortage of ventilators for patient care in OECD DAC list countries. The global pandemic of COVID-19 has highlighted this lack of ventilators which is in-turn compounded by a shortage of trained staff available to operate them. Beyond COVID-19, there remain the critical requirements of caring for pneumonia patients and others suffering from acute respiratory conditions in the OECD DAC-list countries.This project takes as its starting point the HEV (High Energy physics Ventilator) developed by the CERN particle physics laboratory in Geneva with advice and guidance from WHO with the aim of being suitable for OECD DAC list use. HEV has been developed using techniques routinely used in the context of CERN research, including for delivery and regulation of gases, and for sophisticated monitoring and control. Nevertheless, HEV was designed to be reasonably priced, robust, easily maintained and able to operate in an environment where oxygen supply pressure is variable, power is unreliable and few trained staff are available. The result is a resilient and simple design with comprehensive in-built options for remote training, monitoring, and operation, which does not compromise on either performance or functionality, but allows easy operation via a multi-lingual user interface.Within this HPLV project, partners in Brazil will identify local difficulties encountered when ventilating patients and input that information to the design team working on re-engineering the HEV ventilator into an HPLV design. Regulatory experts in the UK will also provide valuable guidance on this re-engineering activity. As well as re-engineering an HPLV prototype in line with real-world advice from Brazil, the HPLV project team will provide the necessary documentation to accompany the HPLV design, such that it is ready for regulatory approval. This is a key milestone to enabling commercial organisations to bridge the gap between prototyping and manufacture for use in a medical environment.The end point of this project will be reached when the new re-engineered HPLV prototype has been successfully tested in Brazil and the technical file is available for companies to use when they license the design for manufacture and sale to OECD DAC list users.