EVOKED POTENTIALS EARLY ALZHEIMERS DISEASE DETECION

研究的目的是确定事件相关电位 被记忆语义加工过程中的事件相关电位（ERPs） 单词可以区分与年龄相关的记忆 （1）在老年痴呆症前期， 阿尔茨海默病（AD）。 AD的诊断非常困难 在最早的阶段，当个人通常经历 近期记忆受损，可能无法与 在AAMI中观察到的。 拟议研究的具体目标是 收件人： 1)重复调查人员的初步调查结果， 轻度AD患者N200-P300波幅和P300潜伏期延长的研究 一个更大的，精心挑选的，神经心理学定义的群体， 实验组和对照组 2)通过跟踪一组受试者， AAMI纵向，以确定这些ERP参数是否可以 预测哪些受试者有患痴呆症的风险。 第一阶段（第1年和第2年）将测量上述ERP参数， 40例符合NINCDS-ADRDA工作组标准的实验受试者 对于AD，可能患有轻度痴呆（全球 恶化量表4）。 他们将接受全面的身体检查， 和心理检查，并进行ERP记录 在经典的听觉beboop范式以及四个 语义单词排序任务。 40名年龄匹配的对照组， 性别和教育水平将接受相同的考试， 企业资源规划程序。 平均N200-P300振幅和P300潜伏期 对每种ERP范式进行组间比较，以测试 for significant显著differences差异. II期（第1 - 5年）将随访100例受试者队列， AAMI纵向。 在第1年和第2年，该队列将 经过全面的身体和心理检查后， 他们的观察和判断， 症状符合全面恶化量表3。 他们将 所有人都接受与本阶段相同的基线ERP程序 I科目。 身体和心理检查和ERP 所有II期受试者将在 第3年或第4年，以及所有可能的II期受试者 在第五年。 预计约10%的 在记忆力测试中，这一组会下降至少一个标准差 和一个或多个其他认知功能。 决心将 他们的ERP参数是否提前并预测了 下降

The research goal is to determine if event-related potentials (ERPs) elicited during semantic processing of to-be-remembered words can differentiate subjects with age-associated memory impairment (AAMI) from those in the pre-dementia stages of Alzheimer's Disease (AD). The diagnosis of AD is very difficult in the earliest stages, when individuals commonly experience impairment of recent memory which may be indistinguishable from that observed in AAMI. The specific aims of the proposed study are to: 1) Replicate the investigators preliminary findings of diminished N200-P300 amplitude and prolonged P300 latency in mild AD, using a larger, carefully selected and neuropsycholigically defined group of experimental and control subjects. 2) Extend these ERP findings by following a group of subjects with AAMI longitudinally, to determine if these ERP parameters can predict which subjects are at risk of developing dementia. Phase I (years 1 and 2) will measure the above ERP parameters in 40 experimental subject meeting NINCDS-ADRDA work group criteria for AD, probable and having a mild level of dementia (Global Deterioration Scale 4). They will receive comprehensive physical and psychological examinations, and ERP recordings will be made during the classic auditory be-boop paradigm as well as four semantic word-sorting tasks. 40 control subjects matched for age, sex, and educational level will undergo identical examinations and ERP procedures. The mean N200-P300 amplitude and P300 latency will be compared between groups for each of the ERP paradigms to test for significant differences. Phase II (years 1 to 5) will follow a cohort of 100 subjects wish AAMI longitudinally. During years 1 and 2, the cohort will be enrolled following comprehensive physical and psychological examinations and determination that they manifest signs and symptoms consistent with Global Deterioration Scale 3. They will all receive baseline ERP procedures identical to those of the Phase I subjects. Physical and psychological examinations and ERP procedures will ba repeated once for all Phase II subjects during year 3 or 4, and once again for all possible Phase II subjects during year 5. It is anticipated that approximately 10% of the cohort will drop at least one standard deviation on tests of memory nd one or more other cognitive functions. A determination will ba made of whether their ERP parameters predated and predicted the drop.