RODENT FOUNDATION COLONIES

该项目的目的是运营、维护和提供 家系，明确的与微生物区系相关的啮齿动物基础群体 为扩大的啮齿动物生产群体提供饲养员 中锋。 从遗传定义的近交系种质中获得的后代 NIH存储库或其他来源将由塞萨里安派生，维护在 隔离物，并与定义的微生物区系相关联。它们的后代 基础畜种将用于为扩建项目提供育种者 以30对繁殖对的速度生产新的啮齿动物群体 在Fischer 344/N大鼠和45对C57BL/6N和C3H/Hen MTV繁育对中- 老鼠和适当数量的繁殖对其他品系每月。 以FISHERCER 344/N大鼠和B6C3F1杂交小鼠为实验动物 用于毒理学和化学物质评价的动物种类 DTRT/NTP下的致癌特性。人类的遗传完整性 Fischer 344/N大鼠及C57BL/6N和C3H/HEN的表观世代 MTV-小鼠产生B6C3F1杂交种对发展至关重要 可靠、准确的动物实验研究数据。集中式 基础菌落将提供更好的遗传完整性控制 所有在扩大和生产啮齿动物群体中的饲养员 生产中心。

The purpose of this project is to operate, maintain and provide pedigreed, defined microflora associated rodent foundation colonies for supplying breeders to the expansion colonies of the rodent production centers. Offspring from genetically defined inbred pedigreed stock obtained from NIH Repository or other sources will be Cesarian derived, maintained in isolators and associated with defined microflora. Offspring from these foundation stock will be used to supply breeders to the expansion colonies of new rodent production colonies at a rate of 30 breeding pairs of Fischer 344/N rats and 45 breeding pairs of C57BL/6N and C3H/HeN MTV- mice and appropriate number of breeding pairs of other strains per month. Fishcer 344/N rats and B6C3F1 hybrid mice are the selected experimental animal species for evaluation of chemicals for toxicologic and carcinogenic properties under DTRT/NTP. The genetic integrity of the apparent generations of Fischer 344/N rats and the C57BL/6N and C3H/HeN MTV- mice to produce the B6C3F1 hybrid is essential for developing reliable and accurate research data in animal experiments. Centralized foundation colonies will provide better control on genetic integrity of all the breeders in the expansion and production colonies of rodent production centers.