课题基金 / 基金详情

EFFECTS OF MATERNAL PKU ON PREGNANCY OUTCOME

EFFECTS OF MATERNAL PKU ON PREGNANCY OUTCOME
母亲 PKU 对妊娠结局的影响
批准号：
3650838
负责人：
REUBEN MATALON
金额：
$6.5万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-05-16 至 1991-05-15
来源：
https://reporter.nih.gov/project-details/3650838
关键词：
academic achievement child (0-11) child physical development child psychology diet therapy embryo /fetus homozygote human population genetics human pregnant subject human subject mother /embryo /fetus nutrition nutrition disorder chemotherapy nutrition related tag perinatal phenylalanine phenylketonurias

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中文摘要
翻译
维持正常妊娠的母体苯丙氨酸水平。 在怀孕的哪个阶段，低苯丙氨酸饮食对 防止母体PKU对发育中的胎儿的影响。 如果 低苯丙氨酸饮食的有益效果可以得到改善， 在怀孕前和怀孕后开始的。 是否 饮食减少了智力迟钝，自然流产， 低出生体重、先天性畸形、神经和行为畸形 在患有高苯丙氨酸血症的母亲的婴儿中发现的缺陷。 酪氨酸和微量金属水平，并确定 补充的影响，如果发现水平低，怀孕 结果。
英文摘要
The level of maternal phenylalanine which will maintain a normal pregnancy. At what stage of pregnancy a low phenylalanine diet is most effective in preventing the effects of maternal PKU on the developing fetus. If the beneficial effects of a low phenylalanine diet can be improved when initiated prior to conception compared to post-conception. Whether the diet reduces the frequency of mental retardation, spontaneous abortions, low birth weight,congenital malformations, neurological and behavioral impairment found in infants of mothers with hyperphenylalaninemia.The levels of tyrosine and trace metals during pregnancy and ascertain the effects of supplementation if levels are found to be low on pregnancy outcome.
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