Stopped-Flow NMR Spectroscopy for the Physical and Life Sciences

核磁共振波谱是科学家可用的最强大的分析技术之一。它信息丰富，提供了关于分子结构、形状和相互作用的细节。因此，核磁共振光谱学是跨物理和生命科学研究的重要工具。在传统的核磁共振波谱中，样品的制备和数据的记录之间不可避免地存在着显著的延迟。因此，当用核磁共振光谱学测量化学变化时，关键信息被遗漏了。这项提议将为一个独特的、具有变革性的核磁共振光谱学包提供资金，其中包括一个停流模块。该模块是第一个商业化的同类设备，允许在光谱仪内制备样品。因此，数据收集可以在样品准备好后立即开始，这意味着可以实时监测一个分子在反应中的整个过程或它与其他物种的相互作用。所要求的仪器还包括一个灵敏的核磁共振光谱仪，仪器的关键电子部件被低温冷却以提高灵敏度。这是至关重要的，因为它将允许更快的数据收集和记录低数量分子的信息的能力。该设备将改变使用核磁共振光谱学的科学家的能力。例如，合成化学家将能够获得关于反应机理的新知识，即一个分子转化为另一个分子的步骤。这将使他们能够设计和发现更有效率和选择性的新流程。例如，通过优化催化剂的结构和性能，可以可持续地制造药物。生物化学家将能够使用这种设备对疾病的化学过程进行直接、定量和非侵入性的研究。这一新知识将使他们能够确定支撑这种生物学的化学物质，并将导致新治疗方法的开发。材料化学家将能够研究电解液和新型液体的溶液状态结构，这将导致改进电池的发展。

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful analytical techniques available to scientists. It is information-rich and provides details on a molecule's structure, shape and interactions. As such, NMR spectroscopy is an essential tool for research across the physical and life sciences. In traditional NMR spectroscopy, there is an unavoidable and significant delay between the preparation of a sample and the recording of data. Therefore, when measuring chemical changes by NMR spectroscopy, critical information is missed.This proposal will fund a unique and transformative NMR spectroscopy package that includes a stopped-flow module. This module, which is the first commercially available device of its type, allows samples to be prepared inside the spectrometer. Therefore, data collection can start immediately after a sample is prepared, which means the full story of a molecule's journey in a reaction or its interactions with other species can be monitored in real time. The requested instrument also includes a sensitive NMR spectrometer, where key electronic parts of the instrument are cryogenically cooled to increase sensitivity. This is essential, as it will allow faster data collection and the ability to record information for molecules that are present in low quantities.The equipment will transform the abilities of scientists who use NMR spectroscopy. For example, synthetic chemists will be able to new gain knowledge of reaction mechanisms, the steps by which one molecule is converted into another. This will allow them to design and discover new processes that are more efficient and selective. For example, medicines maybe sustainably manufactured by optimising the structure and performance of a catalysts. Biological chemists will be able to use this equipment for the direct, quantitative and non-intrusive investigation of the chemical processes of disease. This new knowledge will allow them to identify the chemistry underpinning such biology and will lead to the development of new treatments. Materials chemists will be able to study the solution state structure of electrolytes and novel liquids, which will lead to the development of improved batteries.