RANDOMIZED TRIAL ON THE CLINICAL MANAGEMENT OF ASCUS

卵巢癌ASCUS和LsIL临床处理的随机对照试验 宫颈的设计是为了：L)决定人类 乳头瘤病毒(HPV)检测可以有效地对细胞学检查的妇女进行分流 ASCUS(意义不明的不典型鳞状细胞)的诊断 或LsIL(低度鳞状上皮内病变)发展为临床 管理指南，并为ASCUS和 贝塞斯达系统的LSIL诊断类别，以及3)确定 对潜在前体的筛查和治疗费用 通过改进分诊可以减少宫颈癌的损害。 承包商应负责监督所有产品的质量 审判涉及细胞学和组织病理学的方面。承包商 应审查所有转诊和登记涂片以及所有组织学幻灯片， 以及在试验期间进行的选定的后续细胞学涂片，网址为 临床中心。承包方应召开协商一致会议 在临床中心病理学家之间以及在试验进行期间 监测和优化与病理学有关的议定书的所有方面。 承包商应与研究的协调单位合作， 临床中心、质量控制小组、顾问和国家 癌症研究所项目官员。

The Randomized Trial on the Clinical Management of ASCUS and LSIL of the Uterine Cervix is designed to: l) Determine whether human papillomavirus(HPV) testing can effectively triage women with a cytologic diagnosis of ASCUS (atypical squamous cells of undetermined significance) or LSIL (low-grade squamous intraepithelial lesion) 2) Develop clinical management guidelines and provide prognostic information for the ASCUS and LSIL diagnostic categories of the Bethesda System, and 3) Determine whether the cost of screening and treatment for the potential precursor lesions of cervical cancer can be reduced though improved triage. The Contractor shall be responsible for overseeing the quality of all aspects of the Trial involving cytology and histopathology. The Contractor shall review all referral and enrollment smears and all histology slides, as well as selected follow-up cytology smears taken during the Trial at the Clinical Centers. The Contractor shall conduct consensus meetings among the Clinical Center pathologists and during the conduct of the Trial monitor and optimize all aspects of the Protocol related to pathology. The Contractor shall cooperate with the Study's Coordinating Unit, Clinical Centers, Quality Control Groups, consultants, and the National Cancer Institute Project Officers.