PROSPECTIVE STUDY OF DIET AND CANCER

本合同的目的是进行一项前瞻性队列研究 饮食与几种主要癌症，特别是乳腺癌和 前列腺恶性肿瘤 该队列将主要由男性和 美国退休人员协会（AARP）的女性成员。 在 为了保证足够的异质性饮食摄入的关键 营养素和食物，将分两个阶段建立这一群体。 食物频率调查问卷最初将发送给350万AARP 成员 所有属于以下“极端”类别的受访者 营养物（例如，膳食脂肪）摄入量，然后将选择为最终的 队列，沿着随机抽样的那些属于中间 摄入量的种类。 最后一批将由17.5万人组成， 175，000名女性 将对美国退休人员协会少数族裔成员进行过度抽样， 确保少数群体在最后一批中有足够的代表性。 将对食物频率调查表进行验证研究 在合同期的最初几个月。 后续行动将主要 被动通过建立国家癌症登记;最初的 调查问卷将邮寄给美国退休人员协会成员在这些国家选定的 登记册的覆盖面和质量最低的基础。 活性 将对小百分比进行记录检索的后续工作 已经搬出癌症登记区的队列成员。 的 随访期为五年。

The objective of this contract is to carry out a prospective cohort study of diet in relation to several major cancers, especially breast and prostate malignancies. The cohort will consist primarily of male and female members of the American Association of Retired Persons (AARP). In order to guarantee adequate heterogeneity of dietary intake for key nutrients and foods, the cohort will be established in a two-phase process. Food frequency questionnaires will initially be sent to 3.5 million AARP members. All respondents falling within the 'extreme' categories of nutrient (e.g., dietary fat) intake will then be selected for the final cohort, along with a random sample of those falling within the intermediate categories of intake. The final cohort will consist of 175,000 men and 175,000 women. Oversampling of minority AARP members will be done to ensure an adequate representation of minorities in the final cohort. Validation studies of the food frequency questionnaire will be carried out in the early months of the contract period. Follow-up will be largely passive through established state cancer registries; the initial questionnaire mailing will be to AARP members in those states selected on the basis of having registries with minimum coverage and quality. Active follow-up with record retrieval will be conducted for the small percentage of cohort members who have moved out of the cancer registry areas. The duration of follow-up is five years.