DRUG ABUSE PREVENTION --A LIFECOURSE PERSPECTIVE III

预防研究中心的总体目标是审查 生物、心理和社会因素的相互作用 开始和继续使用和滥用药物，并发展 并测试预防药物滥用的干预策略。该中心曾是 基于以下假设，即预防药物滥用与 寿命，在不同的环境中，它需要跨学科的 透视。预防研究中心的具体目标是； (1)经验性检验源自 与药物滥用有关的生物、心理和社会因素； (2)运用联系不同学科的理论概念，研究、 阐述并阐明存在于 利用动物和人体模型了解病因的研究 药物滥用和预防药物滥用干预措施的有效性；(3) 作为国内和国际病因学的科学资源 药物滥用和预防药物滥用干预措施的有效性；(4) 在国家精神病院内建立预防研究中心 俄罗斯医学科学院健康研究中心 提供必要的指导，使莫斯科中心成为一个可行的 独立实体；以及(5)提供行政、统计和其他 支持所有中心研究人员，招募和培训新的药物滥用 研究人员。 建议进行四项研究：药物反应的个体差异； 动物模型研究了新颖性和 动物的药物寻找行为，重点是中脑边缘多巴胺 系统，环境在调停新奇和毒品搜索中的作用 行为，以及寻求新奇的染色体位置 小鼠基因组上的特征。苯丙胺滥用责任和感觉 寻求地位调查行为影响和滥用责任 苯丙胺等毒品在高、低感寻求者中，以确定 两组之间的差异是否与多巴胺有关 功能。青春期前到成年早期的药物使用模式是一种 对青年时期第一批DARE队列的纵向研究 作为原始DARE评估的一部分收集的五年数据， 检查与药物启动、使用和使用有关的特定病因学问题 继续。青少年吸毒的病因学：选择性预防是一种 严格评估为期六周的创新学习和社交技能 为高危小学生设计的暑期计划。

The overall aim of the Center for Prevention Research is to examine the interaction of biological, psychological and social factors as they relate to the initiation and continuation of drug use and abuse, and to develop and test intervention strategies for drug abuse prevention. The Center was founded on assumptions that drug abuse prevention is relevant across the life span, in different settings, and that it requires an interdisciplinary perspective. The specific aims for the Center for Prevention Research are; (1) Empirically test etiologic models derived from theories of the biological, psychological, and social factors associated with drug abuse; (2) Using theoretical concepts which link different disciplines, examine, elaborate, and articulate the integral connections which exist among research studies using animal and human models to understand the etiology of drug abuse and effectiveness of interventions to prevent drug abuse; (3) Serve as a national and international scientific resource for the etiology of drug abuse and effectiveness of interventions to prevent drug abuse; (4) Establish a Center for Prevention Research within the National mental Health Research Center of the Russian Academy of Medical Sciences and provide the mentoring necessary to make the moscow Center a viable and independent entity; and (5) Provide administrative, statistical, and other support for all Center researchers, and recruit and train new drug abuse researchers. Four studies are proposed: Individual Differences in Drug Response; An Animal Model investigates the biological mechanism linking novelty- and drug seeking behaviors in animals, with a focus on the mesolimbic dopamine system, the role of the environment in mediating novelty- and drug seeking behavior, and the location of chromosomal loci for the novelty seeking trait on the mouse genome. Amphetamine Abuse Liability and Sensation Seeking Status investigates the behavioral effects and abuse liability of amphetamine and other drugs in high and low sensation seekers, to determine whether differences between the two groups are related to dopamine function. Drug Use Patterns of Pre-Teens Into Early Adulthood is a longitudinal study of the first DARE cohort as young adults, building on five years data collected as part of the original DARE evaluation, to examine specific etiologic questions related to drug initiation, use and continuation. Etiology of Adolescent Drug Use: Selective Prevention is a rigorous evaluation of an innovative six-week academic and social skills summer program designed for at-risk elementary school students.