New strategies to produce perfluorinated radiotracers for PET imaging

正电子发射断层扫描（PET）成像是一种分子成像技术，可以提供人体生物过程的定量数据，被医疗保健提供者、制药公司和学术研究人员广泛使用。PET放射性核素氟-18对小分子PET示踪剂的放射性标记有许多有利的性质。目前，可进行放射性标记的小分子的范围和多样性受到现有放射化学方法的限制。该研究金将扩大可用的反应工具包，包括18f全氟化基元，从而通过氧化氟化策略扩大18f放射性示踪剂的范围和广度。利用这种新方法，我们将开发18F-吉西他滨和18F- ef5的合成，这两个高度受欢迎的目标目前无法从[18F]氟化物中获得。该奖学金是高度跨学科的，将提供氟（无线电）化学、自动化、良好生产规范和临床翻译方面的专家培训。

Positron Emission Tomography (PET) imaging is a molecular imaging technique that can provide quantitative data on biological processes in the human body and is widely used by healthcare providers, pharmaceutical companies, and academic researchers. The PET radionuclide fluorine-18 is has many advantageous properties for the radiolabelling of small molecule PET radiotracers. Currently, the range and diversity of small molecules that can be radiolabelled are limited by the radiochemistry methods available. This fellowship will expand the toolkit of reactions available to includes 18F-perfluorinated motifs, and consequently, the range and breadth of 18F-radiotracers through an oxidative fluorination strategy. Using this new method, we will develop syntheses of 18F-Gemcitabine and 18F-EF5, two highly sought after targets currently inaccessible from [18F]fluoride. This fellowship is highly interdisciplinary and will provide expert training in fluorine (radio)chemistry, automation, Good Manufacturing Practice and clinical translation.