TREATMENT OF CANCER WITH HEAVY CHARGED PARTICLES

该计划项目将继续研究重型带电燃料的使用 用于治疗人类癌症的粒子，如氦和霓离子。 质子和氦离子的物理参数允许精确 将提供带电粒子放射治疗，导致高度 近端肿瘤治疗的重大临床进展 眼、眶、颅底、副鼻腔的关键正常结构 鼻窦、椎旁区、腹膜后或骨盆。系统的优化 这些低LET带电粒子的使用将继续，作为LBL光束 可用性许可，通过与其他质子设施合作 在合作临床试验中。 霓虹离子，除了它们的剂量局部化特性外，还提供了更大的 生物有效性，因为他们的高LET。临床上的希望是 在霓虹灯治疗骨肉瘤和软组织肉瘤的初步试验中， 前列腺癌、唾液腺肿瘤、颅底肿瘤等 鼻咽癌、副鼻窦癌、椎旁肿瘤和胆道癌 呼吸道肿瘤。前瞻性试验正在进行中，以确定剂量- 仅定位(质子或氦离子)就相当于剂量- 定位+高LET(霓虹离子)治疗。霓虹灯离子也在 大容量低LET治疗前列腺癌的疗效比较 以及脑内的胶质母细胞瘤。 预计将通过进一步的研究实现更多的临床收益 研究和开发改进的治疗提供技术， 动态共形重带电粒子的具体实现 心理治疗。高LET带电的潜在、非常显著的改善 通过极大地改进构象，粒子疗法将成为可能 肿瘤的高LET剂量区，正常组织的保留 肿瘤的近端和远端。改善治疗计划 将被用来实现这种极有希望的带电粒子形式 心理治疗。 该计划的目标是优化低LET剂量定位 用质子和氦离子治疗，并研究其应用 霓虹离子等高LET光束在治疗人类癌症中的应用。

This program project will continue research in the use of heavy charged particles such as helium and neon ions for treatment of human cancers. The physical parameters of protons and helium ions permit precision charged particle radiation therapy to be delivered, resulting in highly significant clinical advances in the treatment of tumors lying close to critical normal structures in the eye, orbit, skull base, paranasal sinuses, juxtaspinal area, retroperitoneum or pelvis. Optimization of the use of these low-LET charged particles will continue, as LBL beam availability permits, through collaboration with other proton facilities in cooperative clinical trials. Neon ions, in addition to their dose-localizing properties, offer greater biological effectiveness because of their high-LET. Clinical promise has been seen in neon ion preliminary trials in bone and soft tissue sarcoma, prostate cancer, salivary gland tumors, skull base tumors such as nasopharynx and paranasal sinus cancers, juxtaspinal tumors and biliary tract tumors. Prospective trials are underway to determine whether dose- localization alone (Protons or Helium ions) is comparable to dose- localization + high-LET (Neon ions) therapy. Neon ions are also being compared to megavoltage low-LET therapy in treatment of prostate tumors and glioblastoma of the brain. It is expected that added clinical gains will be achieved through further research and development of improved treatment delivery techniques, specifically implementation of dynamic conformal heavy charged particle therapy. Potentially, highly significant improvement in high-LET charged particle therapy will be possible through much improved conformation f the high-LET dose zone to the tumor, with sparing of normal tissues both proximal and distal to the tumor. Improvements in treatment planning will be made to implement this highly promising form of charged particle therapy. The goals of the program are to optimize low-LET dose-localization therapy with protons and helium ions, and to study the application of high-LET beams such as neon ions in the treatment of human cancers.