Control of T helper cells in autoimmunity and anti-tumour responses.

拟议的研究旨在提高我们对调节称为“T辅助”细胞的专门免疫细胞类型及其在自身免疫性疾病模型和抗肿瘤免疫反应中的功能的因素的理解。该项目将研究（1）称为白细胞介素27的信号蛋白在这些过程中的作用，以及（2）最近发现的与人类MS发展相关的几种新基因如何影响T辅助细胞活性。

The proposed studies aim to improve our understanding of the factors that regulate a specialised immune cell type called “T helper” cells and their function in models of autoimmune disease and during anti-tumour immune responses. The project will investigate (1) the role of a signalling protein called Interleukin 27 in these processes and (2) how several novel genes, recently found to be associated with the development of MS in humans, influence T helper cell activity.