GENERAL CLINICAL RESEARCH CENTER

纽约大学医学中心（NYUMC）已经建立了一个 贝尔维尤医院中心的多类别GCRC， 设施12张病床（混合儿科（4）和成人（8））和6 门诊检查室。 此外，重建工作目前正在 在GCRC卫星门诊部完成，该门诊部将包括6个 额外的检查室。 该提案要求批准第34-38年的运作。 私家侦探。 NYUMC GCRC任命William N. Rom，MD，MPH，项目总监 （1991年7月1日生效）世卫组织确立了新的临床研究主题 强调分子生物学和与艾滋病感染有关的疾病 和癌症 纽约大学的工作是多学科的， 科际协作、基础与临床协作 科学家 GCRC进行了大规模翻新，以容纳这些新的 方向 新项目强调母婴艾滋病毒传播， 艾滋病毒感染的治疗方法，细胞因子方法的使用， 结核病的新流行，癌症的新分子疗法， 分子内分泌学，调节炎症和纤维化过程 通过改变粘附分子、生长因子或信号转导， 并使用令人兴奋的新技术（包括PET和 核磁共振 GCRC被几乎所有的临床 部门，项目主任是执行委员会成员 Skirball生物分子医学研究所的委员会， 由纽约大学顶尖的基础科学研究人员组成 一个新 设立的执行咨询委员会审查所有议定书， 批准和优先排序。 GCRC核心实验室已经 重新设计以应对分子和细胞生物学的未来。 新 已经购买了设备，包括DNA合成仪、热分析仪、 循环仪、凝胶电泳仪、组织培养罩和 用于对GCRC执行常规分子生物学功能的培养箱 协议. 更重要的是，核心实验室将提供 通过教授临床研究者的研究技能发挥教育功能 在分子生物学中，竞争资金来开发新的治疗方法， 使用评价细胞因子，生长因子， 和基因治疗。 已建立CDMAS，以提供纽约大学GCRC 拥有最先进的计算机和生物统计学 咨询可用。 位于贝尔维尤医院中心， GCRC可以接触大量人群进行研究，包括许多 艾滋病毒感染者和少数民族。 纽约大学和贝尔维尤大学密切合作 共同确保最高质量的护理和研究调查。

The New York University Medical Center (NYUMC) has established a multicategorical GCRC at Bellevue Hospital Center, providing inpatient facilities for 12 beds (mixed pediatrics (4) and adults (8)) and 6 outpatient examination rooms. In addition, reconstruction is now being completed on a GCRC satellite outpatient unit which will contain 6 additional examination rooms. This proposal requests approval for years 34-38 of operation. The PI. of the NYUMC GCRC appointed William N. Rom, MD, MPH, Program Director (effective 7/1/1991) who has established a new clinical research theme emphasizing molecular biology and the diseases incompassing HIV infection and cancer. The NYU effort is multidisciplinary, with extensive collaboration among departments and between basic and clinical scientists. The GCRC has undergone extensive renovation to accommodate these new directions. New projects emphasize maternal-fetal HIV transmission, new approaches to therapies in HIV infection, use of cytokine approaches in the new epidemic of tuberculosis, novel molecular therapies in cancer, molecular endocrinology, modulating inflammation and fibrotic processes by altering adhesion molecules, growth factors or signal transduction, and evaluating the brain with exciting new technologies including PET and MRI. The GCRC is utilized by practically all of the clinical departments, and the program director is a member of the executive committee of the Skirball Institute for Biomolecular Medicine which is comprised of NYU'S leading basic science researchers. A newly constituted executive advisory committee reviews all protocols for approval and prioritization. The GCRC core laboratory has been redesigned to address the future in molecular and cell biology. New equipment has been purchased, including a DNA synthesizer, thermal cycler, gel electrophoresis apparatus, tissue culture hoods and incubators for performing routine molecular biology functions on GCRC protocols. More importantly, the core laboratory will provide an educational function by teaching clinical investigators research skills in molecular biology to compete for funding to develop new therapies for clinical studies using approaches to evaluate cytokines, growth factors, and gene therapy. A CDMAS has been established to provide NYU GCRC investigators with the most advanced computer and biostatistical consultation available. Located within Bellevue Hospital Center, the GCRC has access to large populations for study, including many HIV-infected individuals and minorities. NYU and Bellevue work closely together to assure the highest quality care and research investigations.