PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE

这一超级基金计划的主要重点仍然是发展和 可用于风险评估的体内和体外生物检测方法的验证 油性和木材保存废物的评估。一个目标是 开发和验证各种不同的特定化学类别 可用于复杂有毒物质风险评估的生物检测方法 混合物。为了实现这一目标，该项目利用了这两种模式 测定化合物和重组混合物相对效价的方法 单个同系物和加性或非加性相互作用 对于混合物是观察到的。在一些研究中，有毒和/或 从特定危险废物获得的混合物的生化效应 选址也已确定。据报道，在确定 某些化合物的相对效力或毒性当量因子(TEF) 已确定的最具毒性的个别化合物，而这 目前，监管机构正在利用这种方法进行风险评估 全世界。

The major focus of this Superfund Program remains the development and validation of in vivo and in vitro bioassays which can be used for risk assessment of oily and wood-preserving wastes. One goal has been to develop and validate a variety of diverse chemical class-specific bioassays that can be utilized for risk assessment of complex toxic mixtures. To achieve this aim, the project has utilized both model compounds and reconstituted mixtures to determine relative potencies of individual congeners and the additive or non-additive interactions which are observed for mixtures. In some studies, the toxic and/or biochemical effects of mixtures obtained from specific hazardous waste sites have also been determined. Progress is reported in determining relative potencies or toxic equivalency factors (TEFs) for some of the most toxic individual compounds that have been identified, and this approach is now being utilized for risk assessment by regulatory agencies worldwide.