GENERAL CLINICAL RESEARCH

加州大学洛杉矶分校综合临床研究中心（GCRC）由USPHS成立 在1973年8月，并提供了一个设施，调查人员与 来自医学院各个学科的批准协议可以 对人体进行研究。 该中心提供设施， 进行这种基础和应用性质的临床研究， 对于那些隶属于加州大学洛杉矶分校的研究人员来说， 药 它也为研究生培养做出了重要贡献 医生、护士和营养师。在过去的三年里，更多 通过UCLA实施的研究产生了100多篇出版物 GCRC。 在提交此更新后发生了重大变化 在我们的GCRC中：任命了新的方案和副主任; 我们建议建立一个核心实验室， 成人和儿科艾滋病相关的研究在GCRC。 在接下来的5年里，44名不同的主要研究人员将 开展以结缔组织疾病为主要代表的研究， 如硬皮病、类风湿性关节炎和SLE; 动脉粥样硬化;癌症与营养;治疗新策略 卵巢癌和乳腺癌;急性脊髓损伤后康复 损伤;治疗成人和儿童患者的代谢性骨病 与全胃肠外营养相关的骨疾病; 预防复发性溃疡出血;使用HIVIG预防 母婴传播艾滋病病毒感染者共34人 成人和儿童患者的艾滋病相关方案;绝经后 雌激素/孕酮干预; 胰岛素抵抗;亨廷顿舞蹈病患者局部脑葡萄糖代谢 疾病;接触违禁药物患者的多巴胺能功能; 部分睡眠的抗抑郁特性的心理生物学 剥夺;遗传性疾病，如谷胱甘肽酶缺乏症、泰-萨二氏病 疾病、共济失调毛细血管扩张症、粘多糖样沉积症I型和 假性甲状旁腺功能减退 我们在这次更新申请中的具体目标 是为了让研究人员能够继续 控制各种疾病的临床研究， 提高人类健康和生活质量。

The UCLA General Clinical Research Center (GCRC) was founded by the USPHS in August 1973, and has provided a facility where investigators with approved protocols from various disciplines in the Medical School could conduct research on human subjects. The Center provides a facility for conducting such clinical research of both basic and applied nature, which is essential for those investigators affiliated with the UCLA School of Medicine. It also contributes materially to the postgraduate training of physicians, nurses and dietitians. Over the last three years, more than 100 publications resulted from studies implemented through the UCLA GCRC. Major changes have occurred with the submission of this renewal in our GCRC: new program and Associate Directors have been appointed; we proposed the establishment of a Core Laboratory and the incorporation of the adults and pediatrics AIDS-related research within the GCRC. During the next 5 years, 44 different Principal Investigators will conduct studies mainly represented by: connective tissue diseases, such as scleroderma, rheumatoid arthritis and SLE; lipids and lipoprotein in atherosclerosis; cancer and nutrition; new strategies for the treatment of ovarian and breast cancer; rehabilitation after acute spinal cord injury; metabolic bone diseases in adult and pediatric patients treated with dialysis; bone disease associated with total parenteral nutrition; prevention of recurrent ulcer hemorrhage; use of HIVIG to prevent maternal-fetal transmission of HIV infection and a total of 34 AIDS-related protocols in adult and pediatric patients; postmenopausal estrogen/progestin interventions; clinical and molecular analyses of insulin resistance; local cerebral glucose metabolism in Huntington's Disease; dopaminergic function in patients exposed to illicit drugs; the psychobiology of the antidepressant properties of partial sleep deprivation; genetic disorders such as arginase deficiency, Tay-Sachs disease, ataxia telangiectasia, mucopolysaccharidosis Type I and pseudohypoparathyroidism. Our specific aims in this renewal application are to make it possible for investigators to continue and stimulate clinical research for the control of diseases of all types and thereby improve the quality of human health and life.