GENERAL CLINICAL RESEARCH CENTER

目前的提案是一个五年的竞争性续期申请， 马萨诸塞州总医院支持其马林克罗特总医院 临床研究中心。 GCRC已满足临床需求 调查人员在马萨诸塞州总医院超过65 年 它由美国国立卫生研究院资助， 三十年来，首先作为代谢研究中心（NIAMD），自1978年以来， 一般临床研究中心（NCRR）。 当前应用程序 要求近2000个病床日（每日研究单位）和1300个 门诊访问。 将利用这些资源的52个协议 代表来自13个单位的65名研究者的临床研究， 在MGH的10个部门。 在目前的提交中， 已经扩大了来自各部门的调查员人数， Mallinckrodt GCRC历史上最活跃的用户之外。 因此，除了内分泌和代谢方面的方案外， 临床研究计划已启动的部门， 骨科、小儿外科、精神病学和传染病科 内科系疾病和肿瘤科。 Mallinckrodt GCRC为广泛的临床试验提供设施， 研究活动，特别是需要频繁、定时的研究 血液和其他体液的收集，创新和复杂 诊断、治疗和生理技术， 饮食、控制睡眠时间表或光照环境。 许多新 协议包括患者谁通常比那些更生病的研究 在过去。 除了最近翻新的设施外， 提供专业的护理，复杂的饮食支持，生物统计， 支持，一个新的计算机系统（RS-1），一个核心实验室， 临床研究者的需求和其他行政支持 进行临床研究所需。 GCRC非常积极地培训医生、护士、营养师， 临床研究的学生。 关于GCRC的教育工作 包括通过若干机制（CAP）支持研究生培训 奖项和私人资助的Mallinckrodt临床研究奖学金）， 导师为基础的培训，一个计划，为医学生，和教学 教学计划 Mallinckrodt GCRC具有悠久的临床卓越历史， 研究，并已在临床有意义的进展的网站 医学六十多年来 它将继续作为 MGH住院患者临床研究的主要研究中心。

The current proposal is a five year competitive renewal application by the Massachusetts General Hospital to support its Mallinckrodt General Clinical Research Center. The GCRC has served the needs of clinical investigators at the Massachusetts General Hospital for more than 65 years. It has been funded by the National Institutes of Health for thirty years, first as a metabolic research center (NIAMD) and since 1978 as a General Clinical Research Center (NCRR). The current application requests almost 2000 patient bed days (per diem research unit) and 1300 outpatient visits. The 52 protocols that will utilize these resources represent clinical research from 65 investigators located in 13 units and 10 departments at the MGH. For the current submission, a major effort has been made to expand the number of investigators from departments outside of the historically most active users of the Mallinckrodt GCRC. Therefore, in addition to protocols in endocrinology and metabolism, new clinical research programs have been initiated by the Departments of Orthopedics, Pediatric Surgery, and Psychiatry and by the Infectious Diseases and Oncology Units of the Department of Medicine. The Mallinckrodt GCRC provides facilities for a broad array of clinical research activities, particularly research requiring frequent, timed collections of blood and other body fluids, innovative and complex diagnostic, therapeutic and physiological techniques, careful control of diets, controlled sleep schedules or light environment. Many of the new protocols include patients who are generally more ill than those studied in the past. In addition to its recently renovated facilities, the GCRC offers expert nursing care, sophisticated dietary support, biostatistical support, a new computer system (RS-1), a Core Laboratory to serve the needs of the clinical investigators, and other administrative support necessary to perform clinical investigation. The GCRC is very active in training physicians, nurses, dietitians, and students in clinical investigation. The educational efforts on the GCRC include post-graduate training supported through several mechanisms (CAP awards and a privately funded Mallinckrodt Clinical Research Fellowship), mentor based training, a program for medical students, and a didactic teaching program. The Mallinckrodt GCRC has a long history of excellence in clinical investigation and has been the site of meaningful advances in clinical medicine for more than six decades. It will continue to serve as the major site for inpatient clinical investigation at the MGH.