PHENOMENOLOGY OF ADRENOCORTICOTROPIC HORMONE (ACTH) MICROPULSES

这项研究的目标是：1)发现微脉冲是否 在人的外周血浆中可检测到促肾上腺皮质激素； 调查幅度、频率、脉冲持续时间和 ACTH微脉冲的脉冲间隔随年龄变化；3) 调查这些参数在严重抑郁症患者中是否发生改变；以及 4)脉动性ACTH分泌变化与治疗结果的相关性 地塞米松抑制试验和24小时尿自由 皮质醇。

The objectives of this study are: 1) to discover whether micropulses of ACTH can be identified in the peripheral plasma of humans; 2) to investigate whether the amplitude, frequency, pulse duration and interpulse interval of ACTH micropulses change with age; 3) to investigate whether these parameters are altered in major depression; and 4) to correlate changes in pulsatile ACTH secretion with results of dexamethasone suppression test and twenty-four hour urinary free cortisol.