PHENOMENOLOGY OF ADRENOCORTICOTROPIC HORMONE (ACTH) MICROPULSES

本研究的目的是：1）发现微脉冲是否 ACTH可以在人的外周血浆中鉴定; 2） 研究振幅、频率、脉冲持续时间和 促肾上腺皮质激素微脉冲间期随年龄变化; 3） 研究这些参数是否在重度抑郁症中改变;以及 4)将ACTH脉动分泌的变化与 地塞米松抑制试验和24小时尿 皮质醇

The objectives of this study are: 1) to discover whether micropulses of ACTH can be identified in the peripheral plasma of humans; 2) to investigate whether the amplitude, frequency, pulse duration and interpulse interval of ACTH micropulses change with age; 3) to investigate whether these parameters are altered in major depression; and 4) to correlate changes in pulsatile ACTH secretion with results of dexamethasone suppression test and twenty-four hour urinary free cortisol.