THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF PAST AND PRESENT

基因组进化的教训正逐渐显露出来 通过对种群分化、遗传分化和 自然人群的疾病模式。 三个系统发育分析 食肉目（猫科动物，熊科，和Procyonidae）已经产生了 形成分类学区分基础的时间顺序 和适应的过程。 历史教训和 持续的流行病和随之而来的基因组适应对于 解释基因组组织的功能背景。 人口 基线医学遗传学和生殖生理学的筛选提供了 对影响物种的生物学策略的新见解 生存和提供更全面的了解物种的相互作用 基因组及其生物环境。 利用分子生物学的方法 遗传学监测序列变异，几个组件，影响 发现了自然种群的稳定性。 后果 在几个濒临灭绝的物种中近亲繁殖是最引人注目的 在佛罗里达美洲狮的案例中有记载。 的全长序列 已经确定了一种从美洲狮分离的新慢病毒。 几 人类T细胞嗜淋巴细胞病毒-I种间转移的实例 （HTLV-I）已经从系统发育重建推断。

The lessons of genomic evolution are gradually revealing themselves through studies of population divergence, genetic differentiation, and disease pattern of natural populations. Phylogenetic analyses of three carnivore orders (Felidae, Ursidae, and Procyonidae) have produced chronological hierarchies that form the basis of taxonomic distinction and adaptation during the carnivore radiations. Lessons of historic and ongoing epidemics and ensuing genomic adaptations are critical to interpreting the functional context of genome organization. Population screens of baseline medical genetics and reproductive physiologies offer recurring new insight into biological strategies that influence species survival and provide a fuller understanding of the interaction of species genomes and their biological environment. Using the methods of molecular genetics to monitor sequence variation, several components that influence stability of natural populations have been discovered. The consequences of close inbreeding in several endangered species is most dramatically documented in the case of the Florida puma. A full-length sequence of a novel lentivirus isolated from pumas has been determined. Several examples of inter-species transfer of human T-cell lymphotropic virus-I (HTLV-I) have been inferred from phylogenetic reconstruction.