Correlating Multiple Sclerosis Risk SNPs with immune cell gene expression

在多发性硬化症（MS）中，免疫系统反复攻击大脑和脊髓。在过去的三年里，在了解MS的遗传风险因素方面取得了快速进展，已知有20多种，但其功能尚不清楚。这项研究将招募MS患者和健康对照，以分离五种主要的免疫细胞类型，并评估风险基因如何影响这些细胞。我们希望更好地了解MS的遗传风险因素是如何起作用的。

In Multiple Sclerosis (MS), the immune system repeatedly attacks the brain and spinal cord. In the last three years, rapid progress has been made in understanding genetic risk factors for MS, and more than 20 are known, but their function is not understood. The proposed study will recruit patients with MS and healthy controls to isolate five major immune cell types, and will assess how risk genes influence these cells. We hope to obtain a much better picture of how genetic risk factors for MS actually work.