课题基金 / 基金详情

MECHANISMS FOR HIV-1 ENHANCEMENT OF EICOSANOID FORMATION

MECHANISMS FOR HIV-1 ENHANCEMENT OF EICOSANOID FORMATION
HIV-1 增强类二十烷酸形成的机制
批准号：
3755461
负责人：
T ELING
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3755461
关键词：
AIDS HIV envelope protein gp120 eicosanoids fatty acid biosynthesis human immunodeficiency virus 1 virus envelope virus protein

项目摘要

项目成果

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中文摘要
翻译
本项目的目的是确定 来自AID病毒的外壳蛋白（GP-120和GP-160）增强了 类花生酸的形成。 我们最初的努力是研究 几种细胞系统，人单核细胞，Jurkat T细胞和 单核细胞系THP-1代谢花生四烯酸的能力， 兰丁 初步结果表明，Jurkat细胞 只有少量的甘草素，可能不是合适的模型。 我们正在测试一些不同的制剂， GP-120和GP-160的抗HIV活性 来自人单核细胞的PGE 2。 我们正处于这方面的早期阶段 调查
英文摘要
The object of this project is to determine the mechanism by which the coat proteins (GP-120 and GP-160) from the AID virus enhances the formation of eicosanoids. Our initial effort was devoted to examining several cellular systems, human monocytes, Jurkat T cells and the monocyte line, THP-1 for their ability of metabolizing arachidonic acid to prostaglandins. Preliminary results indicate that the Jurkat cells form only minor amounts of prostaglandins and may not be a suitable model. We are in the process of testing a number of different preparations of GP-120 and GP-160 from several HIV strain for their ability to stimulate PGE2 from human monocytes. We are in the very early phase of this investigation.
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