PURCHASE HEWLETT PACKARD ULTRASONOGRAPHY UNIT

BRS共享仪器赠款提案将使Temple能够 大学健康科学中心将购买惠普Sonos1500， 它是一种最先进的计算机实时超声设备，具有 多谱勒功能。 至少有10名现役调查人员，其中3人是由NIH资助的，情况危急 这取决于此类设备的可用性。他们被拒绝了 获得类似设备，因为医院法规禁止 在病人护理设施中进行动物研究。拟议的单位将是 被安置在研究设施中，专门用于动物实验。 使用者都需要高分辨率成像和血流测量 在他们的研究中。该工具将在项目中发挥关键作用 涉及1)调控心脏发育的分子机制 肥厚，2)钙稳态在肥厚和高血压中的作用。 心肌细胞下降，3)改善机制的研究 极早产儿脑干功能与脑血流量的关系 动物，4)高渗晶体复苏的效果 脊髓创伤，5)药物处理，以防止 脑缺血再灌注，6)门静脉吻合 肝移植，7)肠系膜上动脉血流 新生儿坏死性脉管炎的基础调查 钠滞留和血管收缩的机制 充血性心力衰竭惠普Sonos 1500将成为非 有创成像和血流测量可用于这些 调查人员；它将提高目前的分辨率和准确性 可用的技术。例如，多普勒技术将取代 放射性微球血流法。 组织计划将由内部咨询监督 该委员会的主席是Barbara Wolfson博士，科长 超声和诊断成像教授；它包括 大学赞助项目管理局的代表 Pi和其他坦普尔学院。该仪器的长期使用是 由内部咨询委员会的监督和 诊断成像科和诊断科主任的承诺 用于支付维护费的药品。最后，这台仪器将被保留 在目前的动物研究设施中；不需要翻新。

The BRS Shared instrumentation grant Proposal will enable Temple University Health Sciences Center to purchase a Hewlett Packard Sonos1500, which is a state-of-the-art computed real time sonography unit with Doppler capability. At least 10 active investigators, 3 of whom are NIH funded, are critically dependent on the availability of such equipment. They have been denied access to comparable equipment because hospital regulations prohibit animal research in patient care facilities. The proposed unit will be housed in research facilities and dedicated to animal experimentation. The users all require high resolution imaging and blood flow measurements in their research. The instrument will play a key role in projects involving 1) molecular mechanisms regulating the development of cardiac hypertrophy, 2) the role of calcium homeostasis in hypertrophied and falling cardiac myocytes, 3) investigation of mechanisms to improve brainstem function and cerebral blood flow in very premature neonatal animals, 4) the efficacy of hypertonic crystalloid resuscitation after spinal cord trauma, 5) pharmaceutical manipulation to prevent damage from cerebral ischemia and reperfusion, 6) portal vein anastamoses following liver transplantation, 7) blood flow in the superior mesenteric artery during neonatal necrotizing vasculitis, 8) investigation of basic mechanisms that contribute to sodium retention and vasoconstriction in congestive heart failure. The Hewlett-Packard Sonos 1500 will make non invasive imaging and blood flow measurements available to these investigators; it will improve the resolution and accuracy of currently available techniques. For example, Doppler techniques will replace radioactive microsphere blood flow methods. The Organizational Plan will be supervised by the internal Advisory Committee which is chaired by Dr. Barbara Wolfson, Chief of the Section of Ultrasound and Professor of Diagnostic Imaging; it includes representatives of the University's Sponsored Projects Administration, the PI and other Temple Faculty. The long term use of this instrument is guaranteed by the oversight of the Internal Advisory Committee and by the commitments of the Chairs of the Departments of Diagnostic imaging and Medicine to cover maintenance costs. Finally, this instrument will be kept in a current animal research facility; no renovations are required.