PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS
PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS
批准号:
3760201
负责人:
CARLETON GAJDUSEK
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Alzheimer's disease Bunyaviridae HIV infections Retroviridae aging amyotrophic lateral sclerosis child (0-11) child physical development culture environmental toxicology evolution human subject human tissue interview latent virus infection mental disorders nervous system disorder nutrition nutrition related tag sex behavior spongiform encephalopathy
中文摘要
对正在消失的原始社会的人类生物学的研究集中在
不同文化背景下的神经学发展和学习模式
在这种孤立的群体中发现的人类条件下的实验。
对男人孤立表达的问题的机会主义调查是
我们大多数研究的方法基础:库鲁-CJD
GSS-FFI、HIV(AIDS)、HTLV-I减缓中枢神经系统病毒感染、衰老和
阿尔茨海默病-S,维生素E,肌萎缩侧索硬化症,精神疾病,中毒性神经病。技术
分子遗传学、生物化学、免疫学、病毒学和领域
文化中的流行病学、临床语言和行为研究
分离株和遗传和/或地理隔离的原始条带产生
比在国际化社会中更容易解释的数据。数据和
密克罗尼西亚、美拉尼西亚、波利尼西亚、南部探险队的标本
美洲、亚洲和非洲在最近的艾滋病毒(AIDS)、HTLV-I
汉坦病毒、PML的JCV和疱疹病毒、CMV和EBV的研究。研究:关于
营养、生殖、生育力、青春期年龄和衰老、遗传
距离和多态,异常的和奇数的高级皮质函数
语言学习、认知风格、计算(无计算
文字或数字)和文化改变的性行为解释
人类神经功能的替代形式,而我们不能
一次考察原始人的自然文化实验
孤立的物种被合并成人类的世界性社区。关注的焦点
库鲁病、ALS-PD、HTLV-I脊髓病、癫痫、家族性高发
帕金森氏症,Viliuisk脑病,其他中枢神经系统退行性变,
歇斯底里障碍,精神分裂症,躁郁症,肿瘤,
甲状腺肿、克汀病、类风湿疾病、糖尿病、哮喘、慢性肺
疾病、疟疾、丝虫病、麻风病、囊虫病等
在这些与世隔绝的群体中的感染产生了广泛的显著影响
发现。亚洲、苏联、欧洲和新近由汉坦病毒引起的HFRS
对美国公认的汉坦病毒进行了研究。人类进化论和
适应高海拔、各种气候、多变的食物供应,
矿物质缺乏、毒性暴露和对严重疾病的反应
或者在适当的人群中研究社会心理压力。
因此,人类中枢神经系统疾病的起因是HTLV-1和HIV逆转录病毒
最早发现并在与世隔绝的环境中研究最好
群体:哥伦比亚图阿马科TSP高发区;吸毒母亲
新泽西州的纽瓦克;古巴的流行性神经病。我们有一个新的
新几内亚和所罗门群岛的HTLV-I原美拉尼西亚变种
一个古老的起源,至少在几千年前与猴子没有联系。
英文摘要
Studies of human biology of vanishing primitive societies focus on
neurologic development and learning patterns in diverse cultural
experiments in the human condition found in such isolated groups.
Opportunistic investigation of problems phrased by man in isolation is
the basis of approach from which most of our studies evolved: kuru-CJD
GSS-FFI, HIV (AIDS), HTLV-I slow virus infections of the CNS, aging and
Alzheimer-s, VE, ALS-PD, mental disease, toxic neuropathies. Techniques
of molecular genetics, biochemistry, immunology, virology, and field
epidemiologic, clinical linguistic and behavioral studies in cultural
isolates and genetic and-or geographically isolated primitive bands yield
more easily interpretable data than in cosmopolitan societies. Data and
specimens from expeditions to Micronesia, Melanesia, Polynesia, South
America, Asia and Africa were valuable in recent HIV (AIDS), HTLV-I
hantavirus, JCV of PML and herpesvirus, CMV and EBV studies. Studies on
nutrition, reproduction, fertility, age of puberty and aging, genetic
distance and pleomorphisms, unusual and odd higher cortical functions in
language learning, cognitive styles, computation (calculation without
words or numbers) and culturally modified sexual behavior elucidate
alternative forms of neurologic functioning for man which we cannot
investigate once the natural cultural experiments in primitive human
isolates are amalgamated into the cosmopolitan community of man. Foci of
high incidence of kuru, ALS-PD, HTLV-I myelopathy, epilepsy, familial
parkinsonism, Viliuisk encephalopathy, other CNS degenerations,
hysterical disorders, schizophrenia, bi-polar psychoses, neoplasms,
goiter, cretinism, rheumatoid diseases, diabetes, asthma, chronic lung
disease, malaria, filariasis, leprosy, cysticercosis, and other
infections in these isolated groups have yielded widely significant
discoveries. HFRS caused by hantaviruses in Asia, USSR, Europe and newly
recognized hantaviruses in the U.S. are studied. Human evolution and
adaptability to high altitude, various climes, variable food supply,
mineral deficiencies, toxic exposures and responses to severe diseases
or social psychologic stress are studied in appropriate populations.
Thus, HTLV-1 and HIV retroviruses as causes of CNS diseases in man were
first found and are best studied in isolated or socially segregated
groups: high incidence TSP focus in Tuamaco, Colombia; drug-using mothers
in Newark, New Jersey; epidemic neuropathy in Cuba. We new have a
proto-Melanesian variant of HTLV-I in New Guinea and Solomon Islands, of
an archaic origin, not associated with monkeys at least for millennia.
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