Bio-Electronic Integrated Devices for Healthcare Applications (BIOTRONICA)

个性化医疗可以为为个体患者量身定制的精准医疗铺平道路，从而改善临床结果和生活质量，并减轻医疗系统的负担。这可以通过表皮或家用生物传感器实时远程监测生理信号，为治疗和干预提供可操作的反馈。然而，提供定量数据的生物医学传感器主要依靠化学、电化学和光学检测方法，这些方法往往复杂且耗时，缺乏便携性，或者需要专业人员和设备。BIOTRONICA将提供一种新型的“即时护理”（point-of-care）非侵入性生物医学设备，这种设备依赖于生物过程产生的电信号，有可能通过从身体运动中收集能量来自我供电，从而实现自动化健康监测、疾病筛查和患者护理的阶段性变化。可以对生物刺激产生电反应的功能材料将通过定制的纳米颗粒墨水，使用最先进的增材制造方法，集成到可穿戴和/或“自己动手”的生物医学传感器中。高精度、快速“打印”技术将用于制造符合要求的微流体装置和表皮传感器，用于体液、力和声音的定量电分析。开发的制造方法将扩展到将基于聚合物纤维的摩擦电纱线集成到机械能收集器中，为可穿戴设备供电。BIOTRONICA将为医疗保健应用结果的生物学和电子学的耦合提供新的基本见解。关于生物信号如何通过身体-设备界面进行转导以可靠地测量和调节生物活动的知识可以在未来导致药物筛选，软机器人和传感器辅助手术中的其他应用。

Personalised medicine can pave the way for precision healthcare that is tailored for the individual patient, thereby improving clinical outcomes and quality-of-life, and reducing the burden on healthcare systems. This can be facilitated by remote monitoring of physiological signals in real-time via epidermal or home-use biosensors that provide actionable feedback for treatment and intervention. However, biomedical sensors that provide quantitative data mostly rely on chemical, electrochemical and optical methods of detection that are often complex and time-consuming, suffering from a lack of portability, or requiring specialist personnel and equipment.BIOTRONICA will deliver a new class of "point-of-care" non-invasive biomedical devices that rely on electrical signals arising from biological processes, with the potential to be self-powered through energy harvested from body movement, thus enabling a step change in automated health monitoring, disease screening and patient care. Functional materials that can produce an electrical response to biological stimuli will be integrated into wearable and/or "do-it-yourself" biomedical sensors via customised nanoparticulate inks using state-of-the-art additive manufacturing methods. High-precision, rapid "printing" techniques will be used to fabricate conformable microfluidic devices and epidermal sensors for quantitative electrical analysis of body fluids, forces and sounds. The fabrication methods developed will be extended tointegrate polymer fiber-based triboelectric yarns into mechanical energy harvesters to power wearable devices.BIOTRONICA will provide new fundamental insight into the coupling of biology and electronics for applied outcomes in healthcare. The knowledge gained on how biological signals are transduced across the body-device interface to reliably measure and regulate biological activities could in future lead to additional applications in drug screening, soft robotics, and sensor-assisted surgery.