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DIURNAL VARIATION STUDY TO SEPARATE STRESS INDUCED HYPERCORTISOLISM

DIURNAL VARIATION STUDY TO SEPARATE STRESS INDUCED HYPERCORTISOLISM
分离压力引起的皮质醇增多症的昼夜变化研究
批准号：
3764462
负责人：
DAVID M COOK
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3764462
关键词：
adrenal disorder adrenocorticotropic hormone circadian rhythms cortisol dosage drug screening /evaluation endocrine disorder chemotherapy hormone therapy human subject human therapy evaluation hyperpituitarism hypoadrenalism stress urinalysis

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中文摘要
翻译
临床上存在皮质醇的最佳用量问题 对于氢化可的松缺乏的患者，要么是因为 垂体促肾上腺皮质激素衰竭或肾上腺功能衰竭。该协议检查 假设详细研究ACTH和皮质醇，以及无尿 接受氢化可的松替代治疗的患者皮质醇可能 允许更合理、更准确地选择替代疗法。
英文摘要
Clinical problems exist as to how much cortisol should optimally be given to patients who are deficient in hydrocortisone, either because of pituitary ACTH failure or adrenal failure. This protocol examines the hypothesis that detailed study of ACTH and cortisol, and urine free cortisol in patients receiving replacement hydrocortisone therapy may allow the more rational and accurate selection of replacement therapy.
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