GENERAL CLINICAL RESEARCH CENTER

纽约大学医学中心(NYUMC)已经建立了一个 贝尔维尤医院中心的多类别GCRC，为住院患者提供 提供12张床位(混合儿科(4张)和成人(8张))和6张床位 门诊检查室。此外，重建工作正在进行中。 在GCRC卫星门诊部完成，该门诊部将包括6个 增设考场。 这项提案要求批准34-38年的运作。圆周率。 任命威廉·N·罗姆，医学博士，公共卫生硕士，项目主任 (1991年7月1日生效)世卫组织确立了新的临床研究主题 重视分子生物学和与HIV感染相关的疾病 和癌症。纽约大学的努力是多学科的，有广泛的 科室之间、基础与临床之间的协作 科学家。 广铁公司已进行大规模的翻新工程，以配合这些新的 方向。新项目强调母婴传播艾滋病毒，新 HIV感染的治疗方法，细胞因子方法的使用 结核病的新流行，癌症的新分子疗法， 分子内分泌学，调节炎症和纤维化过程 通过改变黏附分子、生长因子或信号转导， 用令人兴奋的新技术评估大脑，包括PET和 核磁共振检查。GCRC几乎被所有的临床医生所使用 各部门，项目主任是执行成员 斯基博尔生物分子医学研究所委员会 由纽约大学顶尖的基础科学研究人员组成。一个新的 组成的执行咨询委员会审查所有 批准和确定优先顺序。GCRC核心实验室已经被 重新设计以应对分子和细胞生物学的未来。新的 已经购买了设备，包括DNA合成器，热 循环仪、凝胶电泳仪、组织培养罩和 GCRC上用于执行常规分子生物学功能的孵化器 协议。更重要的是，核心实验室将提供 向临床研究人员传授科研技能的教育功能 在分子生物学领域竞争资金，以开发新的治疗方法 使用各种方法评估细胞因子、生长因子、 和基因疗法。已经建立了一个CDMAS来为纽约大学GCRC提供 拥有最先进的计算机和生物统计学的调查人员 提供咨询服务。位于贝尔维尤医院中心内， GCRC可以接触到大量的人口进行研究，其中包括许多 感染艾滋病毒的个人和少数民族。纽约大学和贝尔维尤密切合作 共同确保最高质量的护理和研究调查。

The New York University Medical Center (NYUMC) has established a multicategorical GCRC at Bellevue Hospital Center, providing inpatient facilities for 12 beds (mixed pediatrics (4) and adults (8)) and 6 outpatient examination rooms. In addition, reconstruction is now being completed on a GCRC satellite outpatient unit which will contain 6 additional examination rooms. This proposal requests approval for years 34-38 of operation. The PI. of the NYUMC GCRC appointed William N. Rom, MD, MPH, Program Director (effective 7/1/1991) who has established a new clinical research theme emphasizing molecular biology and the diseases incompassing HIV infection and cancer. The NYU effort is multidisciplinary, with extensive collaboration among departments and between basic and clinical scientists. The GCRC has undergone extensive renovation to accommodate these new directions. New projects emphasize maternal-fetal HIV transmission, new approaches to therapies in HIV infection, use of cytokine approaches in the new epidemic of tuberculosis, novel molecular therapies in cancer, molecular endocrinology, modulating inflammation and fibrotic processes by altering adhesion molecules, growth factors or signal transduction, and evaluating the brain with exciting new technologies including PET and MRI. The GCRC is utilized by practically all of the clinical departments, and the program director is a member of the executive committee of the Skirball Institute for Biomolecular Medicine which is comprised of NYU'S leading basic science researchers. A newly constituted executive advisory committee reviews all protocols for approval and prioritization. The GCRC core laboratory has been redesigned to address the future in molecular and cell biology. New equipment has been purchased, including a DNA synthesizer, thermal cycler, gel electrophoresis apparatus, tissue culture hoods and incubators for performing routine molecular biology functions on GCRC protocols. More importantly, the core laboratory will provide an educational function by teaching clinical investigators research skills in molecular biology to compete for funding to develop new therapies for clinical studies using approaches to evaluate cytokines, growth factors, and gene therapy. A CDMAS has been established to provide NYU GCRC investigators with the most advanced computer and biostatistical consultation available. Located within Bellevue Hospital Center, the GCRC has access to large populations for study, including many HIV-infected individuals and minorities. NYU and Bellevue work closely together to assure the highest quality care and research investigations.