PREVENTION OF CEREBRAL DYSFUNCTION DURING OPEN HEART SURGERY

这项协议描述了一项旨在检验以下假设的研究 OPC-14117(一种神经保护剂和认知药物)的治疗 增强剂)预防以下中枢神经系统功能障碍 体外循环手术。三组，每组21名受试者 研究：一组服用安慰剂，第二组每天服用60毫克，第三组服用120 OPC-14117 mg/天。这项研究将以随机、双重的方式进行 盲目的安慰剂对照设计。QEEG数据将在一周内收集 手术前和手术中。

This protocol describes a study designed to test the hypothesis that treatment with OPC-14117 ( a neuroprotective agent and cognitive enhancer) prevents central nervous system dysfunction following cardiopulmonary bypass surgery. Three groups of 21 subjects will be studied; one group on placebo, a second on 60mg/day and a third on 120 mg/day of OPC-14117. The study will be conducted as a randomized, double blind, placebo-controlled design. QEEG data will be collected one week prior to and during surgery.