INTERDISCIPLINARY STUDIES IN CANCER EPIDEMIOLOGY

该项目是一个综合性流行病学实验室。 烟草相关癌症的当前关键问题的调查。这个 总体目标是增加我们对病因和预防的知识 与烟草相关的癌症，以及烟草的作用机制 致癌。该计划利用了独特的专业知识 美国健康基金会在以下领域拥有的 烟草流行病学与烟草致癌。 这四个项目是：1)我们的病例对照研究的继续 与烟草相关的癌症。2)猪血红蛋白加合物的研究 烟草特有亚硝胺(TSNA)作为肺和肺的危险指数 口腔癌。3)烟草相关癌症的病例对照研究 以允许与项目1.4的结果进行比较。a 黑人和白人的代谢流行病学研究 烟草致癌物代谢活化与意志的关系 由科学管理核心管理，具有数据管理功能 来自生物统计学和计算机核心的支持。 项目1.重点是低焦油香烟对肺癌的影响 组织学，与环境烟草烟雾相关的癌症风险 暴露，以及与烟草有关的癌症的其他因素，如 癌症家族史、生殖和月经周期史和 外源性荷尔蒙和职业暴露。项目2将决定 肺癌和口腔癌患者TSNA珠蛋白加合物水平的研究 作为决定影响这些加合物水平的因素。项目3 在设计和标准上与项目1相似，并将重点放在风险上 肺癌、口腔癌、食道癌和膀胱癌的致癌因素。 项目4将使用烟草致癌物和尿液中的血红蛋白加合物 与致癌物质活化和解毒有关的代谢物 研究观察到的癌症种族差异的机制 病因学。

This program project is an integrated epidemiology laboratory investigation of current critical issues in tobacco-related cancers. The overall goal is to increase our knowledge of the etiology and prevention of tobacco-related cancers, and of the mechanisms of tobacco carcinogenesis. The program takes advantage of the unique expertise which the American Health Foundation possesses in the disciplines of tobacco epidemiology and tobacco carcinogenesis. The four projects are: 1) a continuation of our case-control study of tobacco-related cancers. 2) an investigation of hemoglobin adducts of tobacco specific nitrosamines (TSNA) as an index of risk for lung and oral cavity cancer. 3) a case-control study of tobacco-related cancers in Blacks to permit comparison with results from project 1. 4) a metabolic epidemiological study in Blacks and Whites to investigate the relationship between metabolic activation of tobacco carcinogens and will be administered by the Scientific Management Core, with data management support from the Biostatistics and Computer Core. Project 1. focuses on the impact of low-tar cigarettes on lung cancer histology, the risk of cancer associated with environmental tobacco smoke exposure, as well as other factors for tobacco related cancers such as family history of cancer, reproductive and menstrual cycle history and exogenous hormones and occupational exposures. Project 2 will determine the level of TSNA globin adduct in lung and oral cancer patients as well as determine factors which affect the level of these adducts. Project 3 is parallel to Project 1 in design and criteria, and will focus on risk factors for cancers of the lung, oral cavity, esophagus and bladder. Project 4 will use hemoglobin adducts of tobacco carcinogens and urinary metabolites related to carcinogen activation and detoxification to investigate mechanisms for the observed racial differences in cancer etiology.