TREATMENT OF CANCER WITH HEAVY CHARGED PARTICLES

该项目将继续研究在使用重电荷 例如氦和氖离子的粒子用于治疗人类癌症。 质子和氦离子的物理参数允许精确 带电粒子放射治疗，导致高度 在肿瘤治疗方面的重大临床进展， 眼睛、眼眶、颅底、鼻旁的重要正常结构 鼻窦、脊柱区域、腹膜后或骨盆。 优化 这些低LET带电粒子的使用将继续下去，因为LBL束流 通过与其他质子设施的合作， 在合作临床试验中。 氖离子，除了它们的剂量定位特性之外，还提供更大的能量。 因为它们的高LET而具有生物学效力。 临床承诺 在骨和软组织肉瘤的氖离子初步试验中发现， 前列腺癌，唾液腺肿瘤，颅底肿瘤，如 鼻咽和副鼻窦癌、脊椎肿瘤和胆道肿瘤 气管肿瘤 正在进行前瞻性试验，以确定剂量- 单独定位（质子或氦离子）与剂量相当- 定位+高LET（氖离子）治疗。 氖离子也被 与兆伏低LET治疗前列腺肿瘤相比 和脑胶质母细胞瘤 预计通过进一步的研究， 研究和开发改进的治疗提供技术， 动态共形重带电粒子具体实现 疗法 高LET充电的潜在的、非常显著的改进 粒子治疗将有可能通过大大改善构象f 高LET剂量区的肿瘤，与正常组织都保留 肿瘤的近端和远端 改善治疗计划 来实现这种极有前途的带电粒子 疗法 该计划的目标是优化低LET剂量定位 治疗质子和氦离子，并研究应用 高LET束，如氖离子，用于治疗人类癌症。

This program project will continue research in the use of heavy charged particles such as helium and neon ions for treatment of human cancers. The physical parameters of protons and helium ions permit precision charged particle radiation therapy to be delivered, resulting in highly significant clinical advances in the treatment of tumors lying close to critical normal structures in the eye, orbit, skull base, paranasal sinuses, juxtaspinal area, retroperitoneum or pelvis. Optimization of the use of these low-LET charged particles will continue, as LBL beam availability permits, through collaboration with other proton facilities in cooperative clinical trials. Neon ions, in addition to their dose-localizing properties, offer greater biological effectiveness because of their high-LET. Clinical promise has been seen in neon ion preliminary trials in bone and soft tissue sarcoma, prostate cancer, salivary gland tumors, skull base tumors such as nasopharynx and paranasal sinus cancers, juxtaspinal tumors and biliary tract tumors. Prospective trials are underway to determine whether dose- localization alone (Protons or Helium ions) is comparable to dose- localization + high-LET (Neon ions) therapy. Neon ions are also being compared to megavoltage low-LET therapy in treatment of prostate tumors and glioblastoma of the brain. It is expected that added clinical gains will be achieved through further research and development of improved treatment delivery techniques, specifically implementation of dynamic conformal heavy charged particle therapy. Potentially, highly significant improvement in high-LET charged particle therapy will be possible through much improved conformation f the high-LET dose zone to the tumor, with sparing of normal tissues both proximal and distal to the tumor. Improvements in treatment planning will be made to implement this highly promising form of charged particle therapy. The goals of the program are to optimize low-LET dose-localization therapy with protons and helium ions, and to study the application of high-LET beams such as neon ions in the treatment of human cancers.