LEAD AND OTHER NEUROTOXINS AS RISK FACTORS FOR AMYOTROPHIC LATERAL SCLEROSIS

暴露在环境神经毒素中可能会增加患上 发生神经退行性疾病，直接或通过 与遗传易感因素的相互作用。工作已经开始 评估环境暴露在这些疾病的病因中的作用 精神错乱。肌萎缩侧索硬化症是一种影响运动的进行性神经系统疾病。 神经元；其病因基本上是未知的。已经制定了一项协议 为环境风险作用的病例对照研究而开发 肌萎缩侧索硬化症的病因学因素主要的假设是 终生累积铅暴露是肌萎缩侧索硬化症的危险因素。铅 将通过测量骨铅来评估暴露，使用新的 发展了X射线荧光技术。其他环境风险 将被调查的因素包括汞、溶剂和 杀虫剂。可能增加易感性的基因多态 对铅或其他神经毒素也将进行研究。这项研究将 参与200人的面谈以及临床和实验室评估 发生肌萎缩侧索硬化症患者和200名临床对照。

Exposure to environmental neurotoxins is likely to increase the risk of developing neurodegenerative diseases, either directly or through interaction with genetic susceptibility factors. Work has begun to assess the role of environmental exposures in the etiology of these disorders. ALS is a progressive neurological disease affecting motor neurons; its etiology is essentially unknown. A protocol has been developed for a case-control study of the role of environmental risk factors in the etiology of ALS. The primary hypothesis is that cumulative lifetime exposure to lead is a risk factor for ALS. Lead exposure will be assessed by measuring bone lead, using the newly developed technology of x-ray fluorescence. Other environmental risk factors which will be investigated include mercury, solvents, and pesticides. Polymorphisms in genes which may increase susceptibility to lead or other neurotoxins will be also be studied. The study will involve interviews and clinical and laboratory assessments for 200 incident ALS patients and 200 clinical controls.