SCOR IN CORONARY AND VASCULAR DISEASES

德克萨斯大学西南医学院的缺血性心脏SCOR 位于达拉斯的中心将继续进行研究， 心肌缺血时的病理生理机制， 进展性心肌梗死 本SCOR的研究工作建立在 从基本机制的阐明 负责心肌缺血及其后果将得到改善 患者护理和康复，以及预防心肌梗死的能力 在某些高危人群中发生心肌梗死。 我们的实验研究 已经提出了代表继续生产性的研究工作， 在过去的14-1/2年里，该计划一直在进行。 但是，临床部分增加了4个新的研究部分 （项目2）我们的缺血SCOR计划，包括新的研究，将 阐明鱼油饮食降低风险的机制 冠状动脉成形术后再狭窄;研究将证明 5-羟色胺和血栓素是否在冠状动脉部位积聚 损伤和狭窄在改变冠状动脉 血管阻力和流动;以及有助于发展核 磁共振成像和光谱学 检测心肌缺血并估计灌注，评估 节段性和整体心室功能，并检测动脉粥样硬化 斑块 此外，还增加了新的研究， 利用分子生物学方法：（a）评估间隙连接蛋白 以及它们在调节细胞间通讯和钙离子 结合并确定它们的功能如何与缺血细胞发生改变 损伤（项目8）和（B）研究组织纤溶酶原之间的相互作用 激活剂及其内源性抑制剂并产生突变组织 可以在相关动物模型中评价的纤溶酶原激活剂（和 后来的患者）的溶栓潜力（项目9）。 一个新 研究部分，将评估有助于实现这一目标的基本机制。 还增加了充血性心力衰竭的发生（项目10）。 我们还增加了新的研究，以评估蛋白酶的作用 在心肌细胞和血管损伤（项目7），并研究的影响， 心肌缺血对心脏微循环的影响（项目4）。 冠状 心脏病仍然是当代西方主要的健康危害 社会 这个缺血性SCOR计划是富有成效的， 对以下方面的贡献：（a）阐明基本病理生理学 参与细胞和血管损伤演变的机制， 心肌缺血和梗死;（B）发展敏感的 急性心肌缺血和梗塞的鉴别方法 并估计其程度;以及（c）提供更好的预后洞察力 因此，选择的有未来缺血性心脏病风险的患者 并发症可以在其发展之前被识别。

The Ischemic Heart SCOR at The University of Texas Southwestern Medical Center at Dallas will continue research directed at elucidating pathophysiological mechanisms operative during myocardial ischemia and evolving myocardial infarction. Research work in this SCOR is built upon the principle that from the elucidation of fundamental mechanisms responsible for myocardial ischemia and its consequences will come improved patient care and rehabilitation, and the ability to prevent myocardial infarction in some individuals at risk. The experimental studies that we have proposed represent continuations of productive research efforts that have been ongoing within this Program during the previous 14-1/2 years. However, 4 new research sections have been added to the Clinical Section (Project 2) of our Ischemic SCOR Program, including new studies that will elucidate mechanisms responsible for fish oil diets reducing the risk of restenosis after coronary angioplasty; studies that will demonstrate whether serotonin and thromboxane accumulation at sites of coronary artery injury and stenosis are important physiologically in altering coronary vascular resistance and flow; and studies that will help develop nuclear magnetic resonance (NMR) imaging and spectroscopy for the noninvasive detection of myocardial ischemia and to estimate perfusion, evaluate segmental and global ventricular function, and detect atherosclerotic plaques. In addition, new research studies have been added that will utilize molecular biology methods to: (a) evaluate gap junction proteins and their role in the regulation of cell-to-cell communication and calcium binding and determine how their function is altered with ischemic cell injury (Project 8) and (b) study the interaction between tissue plasminogen activator and its endogenous inhibitor and develop mutant tissue plasminogen activators that may be evaluated in relevant animal models (and later patients) for their thrombolytic potential (Project 9). A new research section that will evaluate basic mechanisms contributing to the development of congestive heart failure has also been added (Project 10). We have also added new research studies to evaluate the role of proteases in myocyte and vascular injury (Project 7) and study the effects of myocardial ischemia on the cardiac microcirculation (Project 4). Coronary heart disease remains a major health hazard in contemporary western society. This Ischemic SCOR Program has been productive and made important contributions toward: (a) the elucidation of basic pathophysiologic mechanisms involved in the evolution of cellular and vascular damage during myocardial ischemia and infarction; (b) the development of sensitive methods for the identification of acute myocardial ischemia and infarction and estimating their extent; and (c) providing improved prognostic insight so that selected patients at risk for future ischemic heart disease complications may be identified prior to their development.