NUCLEAR MEDICAL IMAGING--SCINTIGRAPHIC IMAGING SYSTEM FOR SMALL ANIMALS

研制了一个模拟层析成像系统样机， 用于小动物成像研究。 与传统的闪烁不同 相机，该系统使用单个位置敏感光电倍增管 管（PMT），以确定闪烁事件的位置内 碘化钠闪烁体。 性能测量和成像研究 在小动物中证实了该系统获得 肺部、心脏、大脑和其他结构的高分辨率图像 在老鼠和豚鼠大小的动物身上。 摄像机连接到 一个商业软件/硬件包，运行在Macintosh计算机上 允许所有常见形式的核医学获取的系统/ 进行的人体研究中常规使用的处理程序 在小动物身上。 该仪器是一种低成本、低线性度的 系统 本项目期间的工作重点是评价 一种低成本、专用、改进的线性系统。 目前这款 所提出的系统将线性脉冲输入到闪存或Σ-Δ ADC。 然后，位置和能量信息将输入到DSP板 在嵌入式计算机中，嵌入到EPROM/FPGA逻辑设计中，或者嵌入到 独立计算机。 该系统的优化输出将 通过视频DAC直接连接到Macintosh。

A prototype analog scintigraphic imaging system has been developed for use in small animal imaging studies. Unlike conventional scintillation cameras, this system uses a single position-sensitive photomultiplier tube (PMT) to determine the location of scintillation events within the sodium iodide scintillator. Performance measurements and imaging studies in small animals confirm the ability of this system to obtain high-resolution images of the lungs, heart, brain, and other structures in animals the size of rats and guinea pigs. The camera is coupled to a commercial software/hardware package, running on a Macintosh computer system that permits all common forms of nuclear medicine acquisition/ processing procedures routinely utilized in human studies to be performed on small animals. The instrument developed is a low-cost, low-linearity system. Work during this project period has focused on an evaluation of a low-cost, special-purpose, improved linearity system. At present, this proposed system will input a linear pulse to a flash or Sigma-Delta ADC. Position and energy information will then be input to either a DSP board within an embedded computer, into an EPROM/FPGA logic design, or to a stand-alone computer. The optimized output from this system will then be directed to the Macintosh through a video DAC.