NEUROPSYCHOLOGICAL AND COGNITIVE STUDIES IN EPILEPSY

我们一直在进行语言组织的成像研究， 正常对照组和癫痫患者。 使用正电子发射 断层扫描（PET），与脑血流（CBF）相关的激活 单词和物体识别，听觉理解，以及音素，单词， 和句子的产生都在大脑中。硬膜下数据 将刺激、PET和磁共振成像（MRI）集成在一起 使用数字图像处理技术。联合刺激和 PET数据使我们能够研究激活和 认知活动的中断，并形成更准确的概念， 大脑功能的组织 这些研究将阐明 功能的区域，如基底颞语言区，这是 当计划对不受控制的癫痫发作进行手术时具有临床重要性。 采用数字信号处理技术， 功能定位。 利用曲面拟合算法， PET、CT、MRI和硬膜下电极位置对齐。 在PET中 在实验中，将静止条件平均并从活化条件中减去 条件下，以揭示在任务期间增加的血流量的区域 性能我们发现PET~CBF和硬膜下的CBF有很高的一致性， 使用多个不同功能TET的刺激映射。这 结果表明，无创性术前功能检查是可行的， 大脑映射，也证明了中断的密切相关性， 和活化研究。

We have been performing imaging studies of language organization in normal controls and patients with epilepsy. Using positron emission tomography (PET), activation of cerebral blood flow (CBF) associated with word and object recognition, auditory comprehension, and phoneme, word, and sentence production are localized in the brain. Data from subdural stimulation, PET, and magnetic resonance imaging (MRI) are integrated using digital image processing techniques. The combined stimulation and PET data allow us to study the relationship between activation and disruption of cognitive activity, and to form more accurate concepts of the organization of cerebral function. These studies will elucidate the function of regions such as the basal temporal language area, which are of clinical importance when surgery for uncontrolled seizures is planned. Digital signal processing tech~niques are used to confirm anatomic localization of functional mapping. Using surface fitting algor~ithms, PET, CT, MRI, and subdural electrode positons are aligned. In PET experiments, rest conditions are averaged and subtracted from activated conditions, in order to reveal reigons of inreased blood flow during task performance. We found a high concordance between PET~CBF and subdural stimulation mapping using a number of different functional tets. This result shows the practicality of noninvasive preoperative functional brain mapping, and also demonstrates the close correlation of disruption and activation studies.