CONSOLIDATED BASIC CANCER RESEARCH PROGRAM

这个项目涉及癌症的遗传学、生物学和病毒学。新的 我们对癌症发病机制认识的主要进展 这些变化是由在 威斯塔尔学院。特异性癌基因在肿瘤发病机制中的作用 已对人类的白血病和淋巴瘤进行了评估，其机制 它们的活性已被确定。此外，最近它还 已经有可能确定T细胞的阿尔法链基因 受体可能在人T细胞癌基因激活中起重要作用 白血病。与血液系统恶性肿瘤有关的新癌基因已被发现 鉴定、克隆和鉴定。 此外，在核领域取得了新的突破。 转移到受精卵中。在这方面的极高成功率 这类实验为我们理解哺乳动物的能力开辟了新的途径 细胞质核因子的发育及其作用研究 在早期胚胎发育过程中。

This program concerns the genetics, biology and virology of cancer. New major developments in our understanding of the mechanisms of malignant transformation have resulted from the investigations carried out at The Wistar Institute. The role of specific oncogenes in the pathogenesis of leukemias and lymphomas in man has been assessed and the mechanisms of their activation have been determined. In addition, very recently it has been possible to establish that the gene for the alpha chain of the T cell receptor may have an important role in oncogene activation in human T cell leukemia. New oncogenes involved in hematopoietic malignancies have been identified, cloned and characterized. In addition new breakthroughs have been achieved in the area of nuclear transfer into fertilized eggs. The extremely high rate of success in this type of experiment opens new avenues in our ability to understand mammalian development and to investigate the role of cytoplasmic nuclear factors during early embryogenesis.