SEX HORMONES AND CANCER

拟议的研究旨在检查激动剂的相互作用 和雌激素受体拮抗剂， 使用新建议的平衡， 方法. 雄激素拮抗作用机制的新假说 雌激素作用将在体外和体内进行测试。 此外，本发明还 在新的研究中观察到对类固醇激素的明显抗性 世界灵长类动物将进行。 血浆和组织表征 类固醇水平以及与转运蛋白和受体的结合将 被执行。 类固醇水平的升高可能是 代谢类固醇的酶缺陷的结果，而不是 将通过几种方法测试受体。 这将包括 比较血浆和体液如唾液中的类固醇水平， 组织类固醇代谢的研究，以及 vivo. 雄激素大量芳构化对雌激素的影响 将确定在雄性松鼠猴中发生的情况。 特别是， 由此产生的大量雌激素的影响，以及 雄激素对青春期发育和季节性体重的影响 变化，将被探索。 （Y）

The proposed studies are designed to examine the interaction of agonists and antagonists with the estrogen receptor and their ability to activate the receptor to the DNA binding state using newly advised equilibrium methods. A new hypothesis for the mechanism of androgen antagonism of estrogen action will be tested both in vitro and in vivo. Additionally, studies of the apparent resistance to steroid hormones observed in New World primates will be carried out. Characterization of plasma and tissue steroid levels as well as binding to transport proteins and receptors will be performed. The possibility that the elevated levels of steroids are the consequence of defects in enzymes that metabolize steroids rather than receptors will be tested by several approaches. This will include comparison of steroid levels in plasma and body fluids such as saliva, studies of steroid metabolism by tissues, and study of steroid dynamics in vivo. The effects of massive aromatization of androgens to estrogens occurring in the male squirrel monkey will be determined. In particular, the influence of the resulting large amounts of estrogens, together with androgens on events such as pubertal development and seasonal weight changes, will be explored. (Y)