IMMUNOGENICITY OF PNEUMOCOCCAL GROUP 9 POLYSACCHARIDE-PROTEIN COMPLEX
IMMUNOGENICITY OF PNEUMOCOCCAL GROUP 9 POLYSACCHARIDE-PROTEIN COMPLEX
肺炎球菌 9 族多糖蛋白复合物的免疫原性
批准号：
3804603
负责人：
C S LU
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
关键词：
Streptococcus pneumoniae Streptococcus pneumoniae vaccine active immunization antibacterial antibody antibody formation bacterial antigens bacterial pneumonia bacterial polysaccharides immunoconjugates immunoglobulin G immunoglobulin M juvenile animal laboratory mouse pregnancy pregnancy immunology tetanus toxoid vaccines
中文摘要
翻译
了解多糖（PS）对免疫应答的调节作用
英文摘要
To understand the modulation of immune response to polysaccharide (PS)
immunogens and attempt to develop a more effective vaccine for prevention
of pneumococcal diseases in young children, we studied the immune response
of young mice to a type 9V PS-tetanus toxoid (TT) conjugate and the effect
of maternal immunization on the immune response of young mice to 9VPS-TT.
Young mice at 2 weeks of age produced IgM antibody to 9VPS or PS-protein
conjugate. However, only 9VPS-TT conjugate induced an IgG antibody
response and an anamestic effect when a second dose of the immunogen was
injected at 2 weeks interval. Aluminum hydroxide gel enhanced the IgG
antibody response to 9VPS-TT but did not augment the response to 9VPS. The
gel also helped in the isotype switching from IgM to IgG.
Maternal immunization before and/or during gestation primed young mice to
respond effectively to 9VPS-TT conjugate immunogen. Injection of pregnant
mice with the conjugate immunogen enhanced the IgG antibody response to
9VPS-TT in the offspring. These results indicated that immunization of
mothers with an optimum dose of 9VPS-TT immunogen before and/or during
pregnancy and in young children with a PS-protein conjugate can provide
young children with an enhanced antibody response to pneumococcal PSs.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
海外基金